Hugues J N, Cédrin Durnerin I
Service de Médecine de la Reproduction, Hôpital Jean Verdier, Bondy.
Contracept Fertil Sex. 1997 Jun;25(6):445-56.
During the last decade, the introduction of GnRH analogs in ovarian stimulati on protocols has greatly improved the outcome of IVF cycles. Through a suppressive effect of hypophyseal secretion, GnRH analogs have allowed to prevent cycle cancellation related to endogenous LH surge and/or premature luteinization. Nevertheless, apart from this beneficial effect, little information has been done about consequences of their administration on residual gonadotroph secretion, ovarian responsiveness to gonadotrophins, quality of oocyte and conceptus, endometrial receptivity. The extreme diversity of long-term and short-term protocols used in clinical practice makes this analysis more difficult. In the first part of this review, the authors examine the several ways of GnRH analogs prescription in order to separate their specific effects on each reproductive function component.
在过去十年中，促性腺激素释放激素（GnRH）类似物引入卵巢刺激方案后，极大地改善了体外受精（IVF）周期的结果。通过对垂体分泌的抑制作用，GnRH类似物能够预防与内源性促黄体生成素（LH）峰和/或过早黄素化相关的周期取消。然而，除了这一有益作用外，关于其给药对残余促性腺激素分泌、卵巢对促性腺激素的反应性、卵母细胞和胚胎质量、子宫内膜容受性的影响，几乎没有相关研究。临床实践中使用的长期和短期方案的极端多样性使得这种分析更加困难。在本综述的第一部分，作者研究了GnRH类似物的几种处方方式，以便区分它们对每个生殖功能组成部分的特定影响。
