Luquin M R
Departamento de Neurología, Clínica Universitario de Navarra, Pamplona, España.
Rev Neurol. 1997 Aug;25 Suppl 2:S180-4.
The high incidence of motor and psychiatric complications in patients on chronic levodopa treatment has lend to the renaissance of the surgery for the treatment of Parkinson's disease. The globus pallidus medialis (GPM) and the thalamic Vim constitute the main surgical targets. At present, their acute location is guaranteed by the development of new neuronal recording systems. Other therapeutical approaches include Vim electrical stimulation for parkinsonian patients with tremor. Chronic electrical stimulation of GPM and subthalamic nucleus (STN) are under evaluation, but preliminary results suggest that this treatment could be of great value in the treatment of patients with Parkinson's disease.
长期接受左旋多巴治疗的患者出现运动和精神并发症的高发生率，使得帕金森病的手术治疗得以复兴。内侧苍白球（GPM）和丘脑腹中间核（Vim）是主要的手术靶点。目前，新的神经记录系统的发展保证了它们的精确位置。其他治疗方法包括对有震颤的帕金森病患者进行Vim电刺激。GPM和丘脑底核（STN）的慢性电刺激正在评估中，但初步结果表明这种治疗方法在帕金森病患者的治疗中可能具有很大价值。
