Järvinen P, Hyvärinen L
Porin Lääkäritalon Työterveys Oy, Department of Occupational Health and Surgery, Finland.
Occup Environ Med. 1997 Jul;54(7):483-6. doi: 10.1136/oem.54.7.483.
To determine whether blurred vision caused by exposure to triethylamine (TEA) can be detected by the measurement of contrast sensitivity.
41 cold box core makers of three foundries and 82 control workers were examined. A detailed ocular and medical history was obtained from the subjects. The contrast sensitivity of the core makers was measured on Monday and Friday of the same week both before and immediately after work and also on a third day, when air samples of TEA were collected. Contrast sensitivity and visual acuity were measured by optotype figures at full contrast, 2.5% contrast, and 0.6% contrast. The changes in contrast sensitivity were used for the analysis. The results of binocular vision and the results of the dominant eye were analysed. Urine specimens for the analysis of TEA were collected on every occasion when contrast sensitivity was measured.
78% of the core makers had had symptoms of blurred vision, and 31% had had trouble driving or working. The breathing zone eight hour time weighted average TEA concentrations were 0.3-60 mg/m3. The mean urinary TEA concentration after the shift was 35 mmol/mol creatinine. Continuous monitoring showed high peaks of TEA leakage at a core making machine. Changes in binocular visual acuity did not differ between the exposed and unexposed workers. The contrast sensitivity decreased in 49% of the core makers and 21% of the controls (P = 0.002).
The blurred vision caused by exposure to TEA can be documented by measuring contrast sensitivity. The mechanism by which TEA produces symptoms remains an issue of further study.
通过测量对比敏感度来确定接触三乙胺(TEA)所致的视力模糊是否可被检测到。
对三个铸造厂的41名冷箱制芯工人和82名对照工人进行了检查。从受试者处获取了详细的眼部和病史。在同一周的周一和周五,分别于工作前、工作后即刻以及在采集TEA空气样本的第三天,对制芯工人的对比敏感度进行测量。通过全对比度、2.5%对比度和0.6%对比度的视标数字来测量对比敏感度和视力。使用对比敏感度的变化进行分析。分析了双眼视力结果和优势眼结果。在每次测量对比敏感度时均采集尿液样本用于TEA分析。
78%的制芯工人有视力模糊症状,31%的人在驾驶或工作时遇到困难。呼吸带八小时时间加权平均TEA浓度为0.3 - 60 mg/m³。轮班后尿TEA平均浓度为35 mmol/mol肌酐。连续监测显示一台制芯机处有TEA泄漏的高峰值。暴露组和未暴露组工人的双眼视力变化无差异。49%的制芯工人和21%的对照组对比敏感度下降(P = 0.002)。
通过测量对比敏感度可证实接触TEA所致的视力模糊。TEA产生症状的机制仍是进一步研究的问题。