生物序列的语言学方法。

Linguistic approaches to biological sequences.

作者信息

Searls D B

机构信息

SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406, USA.

出版信息

Comput Appl Biosci. 1997 Aug;13(4):333-44. doi: 10.1093/bioinformatics/13.4.333.

DOI:10.1093/bioinformatics/13.4.333

PMID:9283748

Abstract

Biologists have long made use of linguistic metaphors in describing and naming cellular processes involving nucleic acid and protein sequences. Indeed, it is very natural to view the genetic 'text' and its sequential transliterations in these terms. However, a metaphor is not a tool, and it is necessary to ask whether the techniques used in analyzing other kinds of languages, such as human and computer languages, can in fact be of any use in tackling problems in molecular biology. This paper reviews the work of the author and others in applying the methods of computational linguistics to biological sequences.

摘要

长期以来，生物学家一直使用语言隐喻来描述和命名涉及核酸和蛋白质序列的细胞过程。事实上，从这些角度来看待遗传“文本”及其顺序转译是很自然的。然而，隐喻并非工具，有必要探讨分析其他类型语言（如人类语言和计算机语言）所使用的技术，实际上是否能用于解决分子生物学中的问题。本文回顾了作者及其他人将计算语言学方法应用于生物序列的工作。