Qadri F, Wennerås C, Albert M J, Hossain J, Mannoor K, Begum Y A, Mohi G, Salam M A, Sack R B, Svennerholm A M
International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka.
Infect Immun. 1997 Sep;65(9):3571-6. doi: 10.1128/iai.65.9.3571-3576.1997.
Vibrio cholerae O139 has recently emerged as the second etiologic agent of cholera in Asia. A study was carried out to evaluate the induction of specific immune responses to the organism in V. cholerae O139-infected patients. The immune responses to V. cholerae O139 Bengal were studied in patients by measuring antibody-secreting cells (ASC), as well as vibriocidal and antitoxic antibodies in the circulation. These responses were compared with those in patients with V. cholerae O1 disease. Strong immunoglobulin A (IgA) and IgM ASC responses were seen against the homologous lipopolysaccharide or serogroup of V. cholerae. The magnitude and isotype of the responses were similar in O139- and O1-infected patients. Vibriocidal antibody responses were seen against bacteria of the homologous but not heterologous serogroup, and these responses reflect the lack of cross-protection between the infections caused by the two serogroups. The two groups of patients showed comparable cholera toxin-specific ASC responses, with the IgG isotype dominating over the IgA isotype, as well as comparable antitoxic immune responses in plasma. These results suggest that despite having a polysaccharide capsule, V. cholerae O139 induces systemic and intestine-derived ASC responses in peripheral blood comparable to those seen in patients with V. cholerae O1 disease.
霍乱弧菌O139最近已成为亚洲霍乱的第二种病原体。开展了一项研究，以评估霍乱弧菌O139感染患者对该病原体特异性免疫反应的诱导情况。通过测量抗体分泌细胞（ASC）以及循环中的杀弧菌抗体和抗毒素抗体，研究了患者对霍乱弧菌O139孟加拉型的免疫反应。并将这些反应与霍乱弧菌O1疾病患者的反应进行了比较。观察到针对霍乱弧菌同源脂多糖或血清群的强烈免疫球蛋白A（IgA）和IgM ASC反应。O139感染患者和O1感染患者的反应强度和亚型相似。观察到针对同源血清群细菌的杀弧菌抗体反应，但未观察到针对异源血清群细菌的反应，这些反应反映了这两个血清群引起的感染之间缺乏交叉保护。两组患者的霍乱毒素特异性ASC反应相当，IgG亚型占主导地位，高于IgA亚型，血浆中的抗毒素免疫反应也相当。这些结果表明，尽管霍乱弧菌O139有多糖荚膜，但它在外周血中诱导的全身和肠道来源的ASC反应与霍乱弧菌O1疾病患者的反应相当。
