Tuomanen E I
Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Pediatr Res. 1997 Sep;42(3):253-8. doi: 10.1203/00006450-199709000-00001.
For 100 y, the study of the molecular mechanism of pneumococcal infection has richly rewarded biomedical science and pediatrics. More recently, a framework has emerged for how the pathogen engineers colonization, invasion of the lung and bloodstream, and finally, entry into the brain. This trafficking is then followed by a separate set of events to generate the symptoms of disease. Understanding the ligand receptor interactions that dictate these events has suggested new concepts for how to control the course of an infectious process and improve the morbidity and mortality of encounters with this prevalent pathogen of children.
一百年来，肺炎球菌感染分子机制的研究极大地推动了生物医学科学和儿科学的发展。最近，一个关于该病原体如何实现定植、侵入肺部和血液，最终进入大脑的框架已经形成。随后，这种转移会引发另一系列事件从而产生疾病症状。了解决定这些事件的配体-受体相互作用，为如何控制感染过程以及降低儿童感染这种常见病原体时的发病率和死亡率提出了新的概念。
