Gratten M, Manning K, Dixon J, Morey F, Torzillo P, Hanna J, Erlich J, Asche V, Riley I
Acute Respiratory Infections Research Laboratory, Queensland Institute of Medical Research, Herston, Brisbane.
Southeast Asian J Trop Med Public Health. 1994 Mar;25(1):123-31.
When nasopharyngeal secretions from 171 Australian Aboriginal children hospitalized with acute lower respiratory tract infections (ALRI) were cultured selectively for Streptococcus pneumoniae and Haemophilus influenzae, 136 (79.5%) and 151 (88.3%) children yielded 166 and 254 isolates of S. pneumoniae and H. influenzae, respectively. In colonized subjects multiple populations of S. pneumoniae (20% of carriage-positive patients) and H. influenzae (55%) were common. Pneumococci belonging to 27 types or groups were identified. H. influenzae serotype b colonized 16.4% of all children studied. More than one half of 152 children tested were excreting antibiotics at the time of admission to hospital. Significantly fewer children with serum antibiotic residues were colonized with S. pneumoniae than were antibiotic free children. Antibiotic usage had no measurable impact on the isolation rate of H. influenzae.
对171名因急性下呼吸道感染（ALRI）住院的澳大利亚原住民儿童的鼻咽分泌物进行了选择性培养，以检测肺炎链球菌和流感嗜血杆菌。结果显示，136名（79.5%）儿童培养出166株肺炎链球菌，151名（88.3%）儿童培养出254株流感嗜血杆菌。在定植者中，多种肺炎链球菌菌群（占携带阳性患者的20%）和流感嗜血杆菌菌群（占55%）很常见。共鉴定出27种肺炎链球菌类型或菌群。b型流感嗜血杆菌定植于所有研究儿童的16.4%。在152名接受检测的儿童中，超过一半在入院时正在排泄抗生素。血清中有抗生素残留的儿童中，肺炎链球菌定植的比例明显低于未使用抗生素的儿童。抗生素使用对流感嗜血杆菌的分离率没有可测量的影响。
