Murray T F, Craigmill A L, Fischer G J
Pharmacol Biochem Behav. 1977 Sep;7(3):239-44. doi: 10.1016/0091-3057(77)90140-x.
A fixed-ratio schedule of water reinforcement (FR-10) was used to examine the relative contributions of pharmacological and behavioral mechanisms in the development of tolerance to the disruptive effects of LSD and mescaline in the rat. Rats treated daily with LSD or mescaline before operant testing developed tolerance to the impairement of responding, while rats treated daily after each session did not display tolerance when the drugs were administered before testing. These results indicate that behavioral compensatory mechanisms may be involved in the development of tolerance to the disruptive effects of LSD and mescaline on fixed-ratio (FR-10) performance.
采用固定比例的水强化程序（FR - 10）来检验药理学和行为学机制在大鼠对麦角酸二乙酰胺（LSD）和三甲氧苯乙胺（mescaline）干扰作用产生耐受性过程中的相对贡献。在操作性测试前每日接受LSD或mescaline处理的大鼠，对反应受损产生了耐受性，而在每次实验后每日接受处理的大鼠，在测试前给药时并未表现出耐受性。这些结果表明，行为补偿机制可能参与了大鼠对LSD和mescaline对固定比例（FR - 10）行为表现的干扰作用产生耐受性的过程。
