内皮细胞PECAM-1/CD31在血管生成中的作用。
Involvement of endothelial PECAM-1/CD31 in angiogenesis.
作者信息
DeLisser H M, Christofidou-Solomidou M, Strieter R M, Burdick M D, Robinson C S, Wexler R S, Kerr J S, Garlanda C, Merwin J R, Madri J A, Albelda S M
机构信息
Department of Medicine, University of Pennsylvania Medical Center, Philadelphia 19104-4283, USA.
出版信息
Am J Pathol. 1997 Sep;151(3):671-7.
The adhesive interactions of endothelial cells with each other and the adhesion receptors that mediate these interactions are probably of fundamental importance to the process of angiogenesis. We therefore studied the effect of inhibiting the function of the endothelial cell-cell adhesion molecule, PECAM-1/ CD31, in rat and murine models of angiogenesis. A polyclonal antibody to human PECAM-1, which cross-reacts with rat PECAM-1, was found to block in vitro tube formation by rat capillary endothelial cells and cytokine-induced rat corneal neovascularization. In mice, two monoclonal antibodies against murine PECAM-1 prevented vessel growth into subcutaneously implanted gels supplemented with basic fibroblast growth factor (bFGF). Taken together these findings provide evidence that PECAM-1 is involved in angiogenesis and suggest that the interactions of endothelial cell-cell adhesion molecules are important in the formation of new vessels.
内皮细胞彼此间的黏附相互作用以及介导这些相互作用的黏附受体，可能对血管生成过程至关重要。因此，我们在大鼠和小鼠血管生成模型中研究了抑制内皮细胞间黏附分子PECAM-1/CD31功能的效果。发现一种与人PECAM-1交叉反应的抗大鼠PECAM-1多克隆抗体，可阻断大鼠毛细血管内皮细胞的体外管状结构形成以及细胞因子诱导的大鼠角膜新生血管形成。在小鼠中，两种抗小鼠PECAM-1单克隆抗体可阻止血管向皮下植入的补充有碱性成纤维细胞生长因子（bFGF）的凝胶中生长。这些研究结果共同提供了证据，表明PECAM-1参与血管生成，并提示内皮细胞间黏附分子的相互作用在新血管形成中很重要。
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