Department of Psychology, Augsburg College, Minneapolis, Minnesota 55455, USA.
Psychophysiology. 2013 Jul;50(7):595-609. doi: 10.1111/psyp.12045. Epub 2013 Apr 25.
This study determined whether time-domain P3 amplitude and time-frequency principal component (TF-PC) reductions are present in adulthood (age 29) when participants have largely passed through the age of heaviest substance misuse. Participants were assessed from age 17 through 29 for lifetime externalizing (EXT) disorders. EEG comparisons from three topographic regions were examined for P3 amplitude and TF-PCs at delta and theta frequency ranges. Significant P3 amplitude reductions were found in those with EXT for both regional and site-Pz analyses, with stronger effects observed the greater the EXT comorbidity. Reductions were also observed in all eight TF-PCs extracted, with a delta component yielding frontal effects not apparent in the time domain. Overall, results suggest that these brain measures continue, at age 29, to provide effective indices of EXT that potentially tap a neural substrate related to behavioral disinhibition.
本研究旨在确定参与者在成年期（29 岁）是否存在时域 P3 振幅和时频主成分（TF-PC）减少的情况，此时他们已经基本度过了滥用物质的高发年龄。参与者从 17 岁到 29 岁进行了终生的外显（EXT）障碍评估。在 delta 和 theta 频带范围内，对来自三个地形区域的 EEG 比较进行了 P3 振幅和 TF-PC 的检查。在具有 EXT 的个体中，无论是在区域还是在 Pz 位置分析中，都发现 P3 振幅有明显减少，且 EXT 共病程度越高，效应越明显。在提取的所有八个 TF-PC 中也观察到了减少，其中 delta 分量产生了在时域中不明显的额部效应。总体而言，研究结果表明，这些大脑指标在 29 岁时仍继续提供 EXT 的有效指标，可能涉及与行为抑制障碍相关的神经基础。
