P3 事件相关电位振幅与外化障碍的关联：对 29 岁成年人的时域和时频研究。
Association between P3 event-related potential amplitude and externalizing disorders: a time-domain and time-frequency investigation of 29-year-old adults.
机构信息
Department of Psychology, Augsburg College, Minneapolis, Minnesota 55455, USA.
出版信息
Psychophysiology. 2013 Jul;50(7):595-609. doi: 10.1111/psyp.12045. Epub 2013 Apr 25.
Abstract
This study determined whether time-domain P3 amplitude and time-frequency principal component (TF-PC) reductions are present in adulthood (age 29) when participants have largely passed through the age of heaviest substance misuse. Participants were assessed from age 17 through 29 for lifetime externalizing (EXT) disorders. EEG comparisons from three topographic regions were examined for P3 amplitude and TF-PCs at delta and theta frequency ranges. Significant P3 amplitude reductions were found in those with EXT for both regional and site-Pz analyses, with stronger effects observed the greater the EXT comorbidity. Reductions were also observed in all eight TF-PCs extracted, with a delta component yielding frontal effects not apparent in the time domain. Overall, results suggest that these brain measures continue, at age 29, to provide effective indices of EXT that potentially tap a neural substrate related to behavioral disinhibition.
摘要
本研究旨在确定参与者在成年期（29 岁）是否存在时域 P3 振幅和时频主成分（TF-PC）减少的情况，此时他们已经基本度过了滥用物质的高发年龄。参与者从 17 岁到 29 岁进行了终生的外显（EXT）障碍评估。在 delta 和 theta 频带范围内，对来自三个地形区域的 EEG 比较进行了 P3 振幅和 TF-PC 的检查。在具有 EXT 的个体中，无论是在区域还是在 Pz 位置分析中，都发现 P3 振幅有明显减少，且 EXT 共病程度越高，效应越明显。在提取的所有八个 TF-PC 中也观察到了减少，其中 delta 分量产生了在时域中不明显的额部效应。总体而言，研究结果表明，这些大脑指标在 29 岁时仍继续提供 EXT 的有效指标，可能涉及与行为抑制障碍相关的神经基础。
相似文献
1
Association between P3 event-related potential amplitude and externalizing disorders: a time-domain and time-frequency investigation of 29-year-old adults.
Psychophysiology. 2013 Jul;50(7):595-609. doi: 10.1111/psyp.12045. Epub 2013 Apr 25.
2
Longitudinal stability and predictive utility of the visual P3 response in adults with externalizing psychopathology.
Psychophysiology. 2015 Dec;52(12):1632-45. doi: 10.1111/psyp.12548. Epub 2015 Sep 24.
3
Is the P3 amplitude reduction seen in externalizing psychopathology attributable to stimulus sequence effects?
Psychophysiology. 2012 Feb;49(2):248-51. doi: 10.1111/j.1469-8986.2011.01299.x. Epub 2011 Sep 19.
4
Substance use disorders, externalizing psychopathology, and P300 event-related potential amplitude.
Int J Psychophysiol. 2003 May;48(2):147-78. doi: 10.1016/s0167-8760(03)00052-7.
5
P3 event-related potential amplitude and the risk for disinhibitory disorders in adolescent boys.
Arch Gen Psychiatry. 2002 Aug;59(8):750-7. doi: 10.1001/archpsyc.59.8.750.
6
Does electroencephalogram phase variability account for reduced P3 brain potential in externalizing disorders?
Clin Neurophysiol. 2014 Oct;125(10):2007-15. doi: 10.1016/j.clinph.2014.02.020. Epub 2014 Mar 6.
7
Deviant P300 amplitude development in males is associated with paternal externalizing psychopathology.
J Abnorm Psychol. 2008 Nov;117(4):910-23. doi: 10.1037/a0013443.
8
The effects of childhood disruptive disorder comorbidity on P3 event-related brain potentials in preadolescents with ADHD.
Biol Psychol. 2008 Dec;79(3):329-36. doi: 10.1016/j.biopsycho.2008.08.001. Epub 2008 Aug 13.
9
Brain-behavior relationships in externalizing: P3 amplitude reduction reflects deficient inhibitory control.
Behav Brain Res. 2018 Jan 30;337:70-79. doi: 10.1016/j.bbr.2017.09.045. Epub 2017 Sep 28.
10
P300 amplitude, externalizing psychopathology, and earlier- versus later-onset substance-use disorder.
J Abnorm Psychol. 2007 Aug;116(3):565-77. doi: 10.1037/0021-843X.116.3.565.
引用本文的文献
1
Midfrontal theta reactivity to conflict and error are linked to externalizing and internalizing respectively.
Personal Neurosci. 2024 Apr 25;7:e8. doi: 10.1017/pen.2023.10. eCollection 2024.
2
Using multivariate endophenotypes to identify psychophysiological mechanisms associated with polygenic scores for substance use, schizophrenia, and education attainment.
Psychol Med. 2021 Mar 18;52(16):1-11. doi: 10.1017/S0033291721000763.
3
Trait Disinhibition and NoGo Event-Related Potentials in Violent Mentally Disordered Offenders and Healthy Controls.
Front Psychiatry. 2020 Dec 11;11:577491. doi: 10.3389/fpsyt.2020.577491. eCollection 2020.
4
Parietal P3 and midfrontal theta prospectively predict the development of adolescent alcohol use.
Psychol Med. 2021 Feb;51(3):416-425. doi: 10.1017/S0033291719003258. Epub 2019 Nov 18.
5
Target-related parietal P3 and medial frontal theta index the genetic risk for problematic substance use.
Psychophysiology. 2019 Aug;56(8):e13383. doi: 10.1111/psyp.13383. Epub 2019 Apr 23.
6
Towards robust biomarkers of psychosocial interventions.
Eur Child Adolesc Psychiatry. 2019 Feb;28(2):153-154. doi: 10.1007/s00787-019-01280-1.
7
Conflict-related medial frontal theta as an endophenotype for alcohol use disorder.
Biol Psychol. 2018 Nov;139:25-38. doi: 10.1016/j.biopsycho.2018.10.002. Epub 2018 Oct 6.
8
What can time-frequency and phase coherence measures tell us about the genetic basis of P3 amplitude?
Int J Psychophysiol. 2017 May;115:40-56. doi: 10.1016/j.ijpsycho.2016.11.008. Epub 2016 Nov 19.
9
Longitudinal stability and predictive utility of the visual P3 response in adults with externalizing psychopathology.
Psychophysiology. 2015 Dec;52(12):1632-45. doi: 10.1111/psyp.12548. Epub 2015 Sep 24.
10
Knowns and unknowns for psychophysiological endophenotypes: integration and response to commentaries.
Psychophysiology. 2014 Dec;51(12):1339-47. doi: 10.1111/psyp.12358.
本文引用的文献
1
Developmental Endophenotypes: Indexing Genetic Risk for Substance Abuse with the P300 Brain Event-Related Potential.
Child Dev Perspect. 2011 Dec 1;5(4):239-247. doi: 10.1111/j.1750-8606.2011.00205.x.
2
Is the P3 amplitude reduction seen in externalizing psychopathology attributable to stimulus sequence effects?
Psychophysiology. 2012 Feb;49(2):248-51. doi: 10.1111/j.1469-8986.2011.01299.x. Epub 2011 Sep 19.
3
The P300 event-related brain potential as a neurobiological endophenotype for substance use disorders: a meta-analytic investigation.
Neurosci Biobehav Rev. 2012 Jan;36(1):572-603. doi: 10.1016/j.neubiorev.2011.09.002. Epub 2011 Sep 21.
4
Alcohol impairs brain reactivity to explicit loss feedback.
Psychopharmacology (Berl). 2011 Nov;218(2):419-28. doi: 10.1007/s00213-011-2323-3. Epub 2011 May 11.
5
Externalizing psychopathology and gain-loss feedback in a simulated gambling task: dissociable components of brain response revealed by time-frequency analysis.
J Abnorm Psychol. 2011 May;120(2):352-64. doi: 10.1037/a0022124.
6
Brain electrophysiological endophenotypes for externalizing psychopathology: a multivariate approach.
Behav Genet. 2010 Mar;40(2):186-200. doi: 10.1007/s10519-010-9343-3. Epub 2010 Feb 13.
7
Relationship between the P3 event-related potential, its associated time-frequency components, and externalizing psychopathology.
Psychophysiology. 2010 Jan 1;47(1):123-32. doi: 10.1111/j.1469-8986.2009.00876.x. Epub 2009 Aug 7.
8
Childhood risk factors for young adult substance dependence outcome in offspring from multiplex alcohol dependence families: a prospective study.
Biol Psychiatry. 2009 Oct 15;66(8):750-7. doi: 10.1016/j.biopsych.2009.05.030. Epub 2009 Jul 29.
9
The effects of childhood disruptive disorder comorbidity on P3 event-related brain potentials in preadolescents with ADHD.
Biol Psychol. 2008 Dec;79(3):329-36. doi: 10.1016/j.biopsycho.2008.08.001. Epub 2008 Aug 13.
10
Association of single nucleotide polymorphisms in a glutamate receptor gene (GRM8) with theta power of event-related oscillations and alcohol dependence.
Am J Med Genet B Neuropsychiatr Genet. 2009 Apr 5;150B(3):359-68. doi: 10.1002/ajmg.b.30818.
Zotero 插件