蛋白质降解：该问题的来龙去脉
Protein degradation: the ins and outs of the matter.
作者信息
Cresswell P, Hughes E A
机构信息
Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, 310 Cedar Street, New Haven, Connecticut 06510, USA.
出版信息
Curr Biol. 1997 Sep 1;7(9):R552-5. doi: 10.1016/s0960-9822(06)00279-x.
PMID:9285707
Abstract
In eukaryotic cells, nascent membrane or secretory proteins are translocated into the endoplasmic reticulum through the Sec61p translocation channel; recent evidence suggests that, if they fail to achieve a native conformation, they are translocated back into the cytosol by the same route and degraded by the proteasome.
摘要
在真核细胞中，新生的膜蛋白或分泌蛋白通过Sec61p转运通道转运到内质网中；最近的证据表明，如果它们未能形成天然构象，就会通过相同途径转运回细胞质，并被蛋白酶体降解。
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