Truelove J, Mueller R, Pulido O, Martin L, Fernie S, Iverson F
Toxicology Research Division, Bureau of Chemical Safety, Food Directorate, Sir F.G. Banting Research Centre, Ottawa, Canada.
Nat Toxins. 1997;5(3):111-4. doi: 10.1002/1522-7189(1997)5:3<111::AID-NT5>3.0.CO;2-6.
Domoic acid was orally administered to 3 cynomolgus monkeys at doses of 0.5 mg/kg for 15 days and then at 0.75 mg/kg for another 15 days. After the 30-day dosing period, the treated monkeys were killed. Parameters monitored as markers for toxicity included body weight, food and water consumption, clinical observations, hematology, serum chemistry, light microscopy of all major organs (including brain and retina), and glial fibrillary acid protein immunohistochemistry. Domoic acid in serum and 24-hour urine samples was measured at several time points. All parameters measured remained unremarkable. Domoic acid concentrations measured in the 24-hour urine samples indicated that gastrointestinal absorption in the monkey was approximately 4-7 percent of the administered dose, which is at least twice that previously reported for the rat.
将软骨藻酸以0.5毫克/千克的剂量口服给予3只食蟹猴，持续15天，然后以0.75毫克/千克的剂量再给予15天。在为期30天的给药期结束后，对接受治疗的猴子实施安乐死。作为毒性标志物监测的参数包括体重、食物和水的摄入量、临床观察、血液学、血清化学、所有主要器官（包括脑和视网膜）的光学显微镜检查以及胶质纤维酸性蛋白免疫组织化学。在几个时间点测量血清和24小时尿液样本中的软骨藻酸。所测量的所有参数均无异常。在24小时尿液样本中测得的软骨藻酸浓度表明，猴子胃肠道的吸收率约为给药剂量的4%至7%，这至少是先前报道的大鼠吸收率的两倍。
