新生儿红斑狼疮

Neonatal lupus erythematosus.

作者信息

Corona R, Angelo C, Cacciaguerra M G, Conti G, De Pità O, Coletti V, el Hachem M, Paradisi M

机构信息

Clinical Epidemiology Unit, Istituto Dermopatico dell'Immacolata, Rome, Italy.

出版信息

Cutis. 2000 Jun;65(6):379-81.

PMID:10879307

Abstract

Neonatal lupus erythematosus (NLE) is a rare disease characterized by the transplacental passage from the mother to the fetus of autoantibodies, in particular anti-Ro(SS-A), anti-La(SS-B), or both. The majority of infants with NLE exhibit isolated congenital heart block, cutaneous lesions analogous to those of adult subacute cutaneous lupus erythematosus, or both. We report a case of NLE in a 3-month-old male infant, born to a clinically asymptomatic mother, presenting small, annular, erythematous plaques with sharp, hyperkeratotic borders and central clearing localized at the eyebrow region. Both the infant and the mother were positive for anti-Ro(SS-A).

摘要

新生儿红斑狼疮（NLE）是一种罕见疾病，其特征是自身抗体经胎盘从母亲传给胎儿，尤其是抗Ro（SS - A）、抗La（SS - B）抗体或两者皆有。大多数患NLE的婴儿表现为孤立性先天性心脏传导阻滞、类似于成人亚急性皮肤型红斑狼疮的皮肤损害，或两者皆有。我们报告一例3个月大男婴患NLE的病例，其母亲临床无症状，患儿眉毛区域出现小的、环形、红斑性斑块，边界清晰、角化过度，中央有消退区。婴儿和母亲的抗Ro（SS - A）抗体均呈阳性。