Sjögren K, Lingström P, Lundberg A B, Birkhed D
Department of Cariology, Faculty of Odontology, Göteborg University, Sweden.
Caries Res. 1997;31(5):366-72. doi: 10.1159/000262420.
The aim was to study the salivary fluoride (F) concentration and plaque pH recovery on the chewing and the non-chewing side of the dentition during and after chewing 1 piece of chewing gum containing 0.25 mg F as NaF. Ten subjects refrained from toothbrushing for 3 days. On the fourth day, they rinsed for 1 min with 10 ml of a 10% sucrose solution. When plaque pH had reached a low value, they started to chew for either 5, 10, 15, 20, 30 or 45 min. Measurements of F concentration in saliva and of pH of approximal plaque were carried out at 2 contralateral sites for up to 60 min. In each individual, the chewing and non-chewing side were registered. Two to 3 times higher salivary F concentrations (expressed as area under the curve, AUC) were found on the chewing than on the non-chewing side (p < 0.05 or p < 0.01). The most pronounced recovery of plaque pH after the sucrose rinse was also registered for the chewing side, but the difference between the chewing and the non-chewing side was not so obvious as for the salivary F concentration. Significantly higher values of plaque pH (expressed as AUC) were found during prolonged chewing (p < 0.05 or p < 0.01), while only small numerical differences in salivary F concentration were noted between short and long chewing times. Thus, this study showed: (1) that the F concentrations in saliva after chewing a F-containing chewing gum were highest on the chewing side, and (2) that a prolonged chewing time increased the plaque pH recovery after a sucrose rinse, but had only a minor effect on the salivary F concentration.
目的是研究在咀嚼 1 片含 0.25mg 氟化钠（NaF）的口香糖期间及之后，牙列咀嚼侧和非咀嚼侧的唾液氟（F）浓度及菌斑 pH 值恢复情况。10 名受试者连续 3 天不刷牙。在第 4 天，他们用 10ml 10%的蔗糖溶液漱口 1 分钟。当菌斑 pH 值达到低值时，他们开始咀嚼 5、10、15、20、30 或 45 分钟。在 2 个对侧部位测量唾液中的 F 浓度和邻面菌斑的 pH 值，持续 60 分钟。在每个个体中，记录咀嚼侧和非咀嚼侧。发现咀嚼侧的唾液 F 浓度（以曲线下面积，AUC 表示）比非咀嚼侧高 2 至 3 倍（p < 0.05 或 p < 0.01）。蔗糖漱口后，菌斑 pH 值恢复最明显的也是咀嚼侧，但咀嚼侧和非咀嚼侧之间的差异不如唾液 F 浓度那么明显。在长时间咀嚼期间，菌斑 pH 值（以 AUC 表示）显著更高（p < 0.05 或 p < 0.01），而短时间和长时间咀嚼的唾液 F 浓度仅存在微小的数值差异。因此，本研究表明：（1）咀嚼含氟口香糖后，唾液中的 F 浓度在咀嚼侧最高；（2）延长咀嚼时间可增加蔗糖漱口后菌斑 pH 值的恢复，但对唾液 F 浓度影响较小。
