Mortazavi Shiva, Aslani Abolfazl, Babaee Mehrnoush, Hajiahmadi Maryam
Department of Pediatric Dentistry, Dental Research Centre, Faculty of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Pharmaceutics, School of Pharmacy, Novel Drug Delivery Systems Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Contemp Clin Dent. 2019 Jan-Mar;10(1):117-122. doi: 10.4103/ccd.ccd_509_18.
Dental caries is a prevalent disease worldwide. or Miswak could be a source of fluoride and has caries preventive effects.
The aim of this study was to compare saliva fluoride concentration and flow rate after using Persica and sodium fluoride chewing gums.
In a triple-blind crossover randomized trial, 44 healthy volunteers (21-25 year old) were recruited according to the inclusion criteria and were randomly allocated into two groups (22 each).
This study was performed within two sets of trial with a 10-day washout period. Participants (subjects) were followed a running period and matched for trial confounders. Saliva samples were collected under controlled conditions at similar time (11 am) within baseline, 5, 10, 20, and 45 min intervals preceded by 5-min chewing of Persica or sodium fluoride chewing gum. Saliva samples were analyzed for fluoride ion using hexamethyldisiloxane diffusion method.
Saliva flow rate (ml/min) and mean fluoride concentration (ppm) during different time periods in two types of gum were compared using ANOVA-repeated measures ( < 0.05).
The difference in total means of stimulated saliva flow rates between two Persica and sodium fluoride gum intervention groups was statistically significant ( = 0.048); however, difference of fluoride concentrations was not statistically significant ( = 0.244).
Chewing Persica containing gum released fluoride ions in saliva and increased saliva flow rate comparable with sodium fluoride chewing gum use as a gold standard.
龋齿是一种在全球范围内普遍存在的疾病。咀嚼棒可能是氟的一个来源，并具有预防龋齿的作用。
本研究的目的是比较使用佩尔西卡（Persica）口香糖和氟化钠口香糖后唾液氟浓度和流速。
在一项三盲交叉随机试验中，根据纳入标准招募了44名健康志愿者（21 - 25岁），并随机分为两组（每组22人）。
本研究在两组试验中进行，有10天的洗脱期。参与者在一个运行期内接受观察，并对试验混杂因素进行匹配。在基线、5、10、20和45分钟间隔（在咀嚼佩尔西卡或氟化钠口香糖5分钟之前）的相似时间（上午11点），在受控条件下收集唾液样本。使用六甲基二硅氧烷扩散法分析唾液样本中的氟离子。
使用重复测量方差分析（<0.05）比较两种口香糖在不同时间段的唾液流速（毫升/分钟）和平均氟浓度（ppm）。
佩尔西卡口香糖和氟化钠口香糖干预组之间刺激唾液流速的总均值差异具有统计学意义（=0.048）；然而，氟浓度差异无统计学意义（=0.244）。
咀嚼含佩尔西卡的口香糖可使唾液中释放氟离子，并使唾液流速增加，与作为金标准的氟化钠口香糖相当。
