Liu D, Diorio J, Tannenbaum B, Caldji C, Francis D, Freedman A, Sharma S, Pearson D, Plotsky P M, Meaney M J
Developmental Neuroendocrinology Laboratory, Douglas Hospital Research Center, McGill University, Montreal, Canada H4H 1R3.
Science. 1997 Sep 12;277(5332):1659-62. doi: 10.1126/science.277.5332.1659.
Variations in maternal care affect the development of individual differences in neuroendocrine responses to stress in rats. As adults, the offspring of mothers that exhibited more licking and grooming of pups during the first 10 days of life showed reduced plasma adrenocorticotropic hormone and corticosterone responses to acute stress, increased hippocampal glucocorticoid receptor messenger RNA expression, enhanced glucocorticoid feedback sensitivity, and decreased levels of hypothalamic corticotropin-releasing hormone messenger RNA. Each measure was significantly correlated with the frequency of maternal licking and grooming (all r's > -0.6). These findings suggest that maternal behavior serves to "program" hypothalamic-pituitary-adrenal responses to stress in the offspring.
母性关怀的差异会影响大鼠对应激的神经内分泌反应中个体差异的发展。成年后，在出生后前10天接受更多舔舐和梳理的母鼠所生的后代，对急性应激的血浆促肾上腺皮质激素和皮质酮反应降低，海马糖皮质激素受体信使核糖核酸表达增加，糖皮质激素反馈敏感性增强，下丘脑促肾上腺皮质激素释放激素信使核糖核酸水平降低。每项指标均与母性舔舐和梳理的频率显著相关（所有r值均> -0.6）。这些发现表明，母性行为有助于“设定程序”后代下丘脑-垂体-肾上腺对应激的反应。
