Fotherby M D, Potter J F
University Department of Medicine for the Elderly, Glenfield Hospital, Leicester, UK.
Int J Clin Pract. 1997 Jun;51(4):219-22.
Following a randomised cross-over trial of the effect of a four-week 60 mmol/day potassium supplement versus placebo on blood pressure (BP), eight of the original 18 hypertensive subjects continued with a 48 mmol daily potassium supplement for four months. For these eight subjects 24-h potassium excretion during placebo, one month of 60 mmol and four months of 48 mmol daily potassium supplementation phases was 56 +/- 23, 102 +/- 28 and 90 +/- 35 mmol/24 hours, respectively, and mean 24-h BP following each phase was 160 +/- 16/89 +/- 11, 147 +/- 13/83 +/- 12 and 145 +/- 14/81+/- 9 mmHg respectively, a significant fall in mean 24-h SBP between four months of potassium supplement and placebo period of 15 +/- 13 mmHg (95% CI: 4, 26 mmHg, p = 0.02), although the fall in 24-h DBP was not significant (8 +/- 11 mmHg, 95% CI: 0, 17 mmHg, p = 0.08). Modest increases in dietary potassium intake could have significant effects on lowering BP in the large proportion of elderly subjects with hypertension.
在一项关于每日补充60毫摩尔钾为期四周与安慰剂对血压（BP）影响的随机交叉试验之后，最初18名高血压受试者中的8名继续每日补充48毫摩尔钾，为期四个月。对于这8名受试者，在安慰剂阶段、每日补充60毫摩尔钾的一个月阶段和每日补充48毫摩尔钾的四个月阶段，24小时钾排泄量分别为56±23、102±28和90±35毫摩尔/24小时，每个阶段后的平均24小时血压分别为160±16/89±11、147±13/83±12和145±14/81±9毫米汞柱，在补充钾四个月与安慰剂阶段之间，平均24小时收缩压显著下降15±13毫米汞柱（95%置信区间：4, 26毫米汞柱，p = 0.02），尽管24小时舒张压的下降不显著（8±11毫米汞柱，95%置信区间：0, 17毫米汞柱，p = 0.08）。适度增加饮食中钾的摄入量可能对降低大部分老年高血压患者的血压有显著作用。
