Raitiola H S, Pukander J S
Department of Otorhinolaryngology, University of Tampere Medical School, Finland.
Acta Otolaryngol Suppl. 1997;529:215-7. doi: 10.3109/00016489709124126.
In order to evaluate the etiological factors, all 318 cases of laryngeal cancer diagnosed during the period of 1962-91 in the Tampere University Hospital area with a population of 400,000 were reviewed. Among males the annual age-adjusted incidence decreased significantly from 7.1 to 2.3 per 100,000. No significant difference in the occurrence was found between urban and rural areas. In males the relative risk (RR) was significantly higher in the lower socio-economic groups. In both sexes smokers had significantly higher risk compared to non-smokers. For male smokers RR was 15.5 (95% CI 10.0-25.4) and for female smokers 12.4 (95% CI 3.9-39.5). Changes in smoking habits seem to be the most important factor contributing to the decreasing incidence of laryngeal cancer in Finland, but other factors like changes in dietary and sauna habits may also have some significance.
为评估病因，我们回顾了1962年至1991年间坦佩雷大学医院地区确诊的318例喉癌病例，该地区人口为40万。男性的年龄调整后年发病率从每10万人7.1例显著降至2.3例。城乡之间在发病率上未发现显著差异。在男性中，社会经济地位较低的群体相对风险（RR）显著更高。在两性中，吸烟者的风险均显著高于非吸烟者。男性吸烟者的RR为15.5（95%置信区间10.0 - 25.4），女性吸烟者的RR为12.4（95%置信区间3.9 - 39.5）。吸烟习惯的改变似乎是芬兰喉癌发病率下降的最重要因素，但饮食和桑拿习惯的改变等其他因素可能也有一定意义。
