McHugh G J, Wild D J, Havill J H
Intensive Care Unit, Waikato Hospital, Hamilton, New Zealand.
Anaesth Intensive Care. 1997 Aug;25(4):350-3. doi: 10.1177/0310057X9702500404.
Three groups of polyurethane central venous catheters (CVC) were infused daily for twenty days with 0.1 normal hydrochloric acid, 70% ethanol and normal saline (control) respectively to look for any changes in microscopic structural integrity. A 1 cm segment was cut from the distal end of each CVC daily. All sections were examined in a scanning electron microscope, looking for evidence either of damage to the lumen surface or of wall thinning. No significant damage to the lumen surfaces was observed with either treatment. Sporadic fine surface-pitting appeared late in the study without any clear temporal or treatment-related pattern. The mean CVC wall thickness did not change significantly over the study period (P = 0.15). Qualitative softening of ethanol treated catheters was observed, and this finding limits the recommendations for the use of ethanol. 0.1N HCl does not compromise the structural safety of the catheters, and its use should be considered when polyurethane CVC. become occluded.
将三组聚氨酯中心静脉导管（CVC）分别每日注入0.1当量盐酸、70%乙醇和生理盐水（对照组），持续二十天，以观察微观结构完整性的任何变化。每天从每个CVC的远端切下1厘米长的片段。所有切片均在扫描电子显微镜下检查，寻找管腔表面损伤或管壁变薄的证据。两种处理均未观察到管腔表面有明显损伤。在研究后期出现了散在的微小表面凹痕，没有任何明确的时间或与处理相关的模式。在研究期间，CVC的平均壁厚没有显著变化（P = 0.15）。观察到乙醇处理的导管有定性的软化现象，这一发现限制了乙醇使用的建议。0.1N HCl不会损害导管的结构安全性，当聚氨酯CVC堵塞时应考虑使用它。
