Ranchère J Y, Tabone E, Latour J F
Centre Régional de Lutte contre le Cancer, Lyon.
Ann Fr Anesth Reanim. 1988;7(6):517-9. doi: 10.1016/s0750-7658(88)80093-5.
An in vitro study of the effect of cytotoxic drugs on polyurethane catheters was carried out. The drugs used--vincristine, doxorubicin, cisplatin and carmustine--damage the surface of silicone elastomer catheters. The irregularities produced seem to be preferential sites for thrombus formation and adhesion of bacterial microcolonies. Electron microscopy examination of the catheters dipped in the drug solutions for different time intervals revealed the appearance of different patterns of damage. The irregularities produced seemed to be less pronounced than for silicone catheters. Polyurethane was highly sensitive to doxorubicin. These changes could well have clinical repercussions. The compatibility of catheters and drugs should be routinely tested before being put on the market.
开展了一项关于细胞毒性药物对聚氨酯导管影响的体外研究。所使用的药物——长春新碱、阿霉素、顺铂和卡莫司汀——会损害硅橡胶弹性体导管的表面。所产生的不规则处似乎是血栓形成和细菌微菌落黏附的优先部位。对浸泡在不同时间间隔的药物溶液中的导管进行电子显微镜检查，发现了不同的损伤模式。所产生的不规则处似乎不如硅橡胶导管明显。聚氨酯对阿霉素高度敏感。这些变化很可能会产生临床影响。导管与药物的兼容性在投放市场前应进行常规测试。
