与自发性高血压大鼠相比，糖尿病易感性和抗性大鼠品系的血压和心率的昼夜变化。
Circadian variations in blood pressure and heart rate in diabetes prone and resistant rat strains compared with spontaneously hypertensive rats.
作者信息
Berg S, Dunger A, Vogt L, Klöting I, Schmidt S
机构信息
Gerhardt Katsch Institute of Diabetes of the Ernst-Moritz-Arndt University Greifswald, Karlsburg, Germany.
出版信息
Exp Clin Endocrinol Diabetes. 1997;105 Suppl 2:7-9. doi: 10.1055/s-0029-1211784.
Circadian blood pressure (BP), heart rate (HR) and motor activity (MA) of nondiabetic (nd) and spontaneously diabetic (d) BB/OK rats were compared with that of spontaneously hypertensive rats (SHR). In addition a diabetes-resistant and non-hypertensive rat strain (LEW.1W) was monitored for the same parameters. Systolic and diastolic BP (SBP, DBP), HR and MA were measured telemetrically. In d BB rats, the 24 h mean value of SBP (132 +/- 0.15 mm-Hg) was significantly increased compared to nd BB rats (125 +/- 0.18 mmHg). No differences were found in DBP between d and nd BB rats (93 +/- 0.13 v.s. 94 +/- 0.15 mmHg). Both, d and nd BB rats were significantly different in SBP and DBP to that of SHR (155 +/- 0.19 and 110 +/- mmHg). Nondiabetic BB rats did not significantly differ from LEW.1W rats in SBP and DBP (125 vs. 123 mmHg and 94 vs. 94 mmHg). The heart rate was lowest in diabetic BB rats compared with all other strains. Compared to nd BB the diabetic rats had an altered daily rhythm in BP. The results demonstrate that the diabetic BB rats develop circadian variations in BP and HR similar to those observed in hypertensive rats.
将非糖尿病（nd）和自发性糖尿病（d）BB/OK大鼠的昼夜血压（BP）、心率（HR）和运动活动（MA）与自发性高血压大鼠（SHR）进行比较。此外，还监测了一种抗糖尿病且非高血压的大鼠品系（LEW.1W）的相同参数。通过遥测法测量收缩压和舒张压（SBP、DBP）、心率和运动活动。在糖尿病BB大鼠中，SBP的24小时平均值（132±0.15毫米汞柱）与非糖尿病BB大鼠（125±0.18毫米汞柱）相比显著升高。糖尿病和非糖尿病BB大鼠的DBP未发现差异（93±0.13对94±0.15毫米汞柱）。糖尿病和非糖尿病BB大鼠的SBP和DBP与SHR（155±0.19和110±毫米汞柱）均有显著差异。非糖尿病BB大鼠的SBP和DBP与LEW.1W大鼠无显著差异（125对123毫米汞柱和94对94毫米汞柱）。糖尿病BB大鼠的心率与所有其他品系相比最低。与非糖尿病BB大鼠相比，糖尿病大鼠的血压日节律发生了改变。结果表明，糖尿病BB大鼠的血压和心率出现昼夜变化，与高血压大鼠中观察到的情况相似。
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