Zhao X J, Hoheisel G, Schauer J, Bornstein S R
Department of Internal Medicine I, University of Leipzig, Germany.
Horm Metab Res. 1997 Aug;29(8):373-8. doi: 10.1055/s-2007-979058.
Corticotropin-releasing hormone-binding protein (CRH-BP), predominately produced by the liver, is a glycoprotein with a molecular weight of 37 kDa. The mature protein consists of 7 exons and 6 introns, with 5 tandem disulfide bridges which are essential for the binding of corticotropin-releasing hormone (CRH). This binding protein is distributed and expressed differently from corticotropin-releasing hormone receptors (CRH-Rs), as is the ligand requirement. Most CRH in plasma is bound to its binding protein, is therefore inactive and unable to bind to its receptor. Other competitives can reverse the binding, liberating CRH. Together with the CRH neuropeptides and CRH receptors, CRH-binding protein plays a role in the hypothalamic-pituitary-adrenal axis, in immune/inflammatory reactions as an auto/paracrine proinflammatory regulator, in pregnancy, as well as in some pathological conditions.
促肾上腺皮质激素释放激素结合蛋白（CRH-BP）主要由肝脏产生，是一种分子量为37 kDa的糖蛋白。成熟蛋白由7个外显子和6个内含子组成，有5个串联二硫键，这些二硫键对于促肾上腺皮质激素释放激素（CRH）的结合至关重要。这种结合蛋白的分布和表达与促肾上腺皮质激素释放激素受体（CRH-Rs）不同，其配体需求也不同。血浆中的大多数CRH与其结合蛋白结合，因此无活性，无法与其受体结合。其他竞争性物质可逆转这种结合，释放出CRH。CRH结合蛋白与CRH神经肽和CRH受体一起，在下丘脑-垂体-肾上腺轴、作为自身/旁分泌促炎调节剂的免疫/炎症反应、妊娠以及某些病理状况中发挥作用。
