Mitsibounas D N, Kosmaidou Z, Kontoleon P, Deligeoroglou E, Liberatou E
Therapeutic Clinic, University of Athens, Greece.
J Pediatr Adolesc Gynecol. 1997 Aug;10(3):133-9. doi: 10.1016/s1083-3188(97)70073-1.
The investigation of differences in the medical status between girls with Turner's syndrome or mosaic variance and healthy girls of the same age. In addition, the existence of differences between those persons with full Turner's syndrome and those with mosaic variance were examined. The influence of the treatment was also of concern because a number of the subjects in the study group were being treated with hormones (estrogen and progestin). Investigation concerned cardiovascular abnormalities, bone age, and lipid and hormonal profiles of the participating persons.
Girls came to the hospital with problems in their menstrual cycles. Genetic control (karyotyping) took place. Each patient with symptoms of Turner's syndrome or mosaic variance was included in the study group. Every third patient with no symptoms of the syndromes and near the same age were included in the control group.
Stratification was made according to the body mass index of the participating persons. Nonparametric tests were used for the analysis.
Differences were detected in the levels of cholesterol, low-density lipoproteins (LDLs), high-density lipoproteins (HDLs), and triglycerides, and were increased in the study group. Presence of thyroid autoantibodies, antithyreo-globulin-antibodies (AASTs) and antimicrosomatic antibodies (AASMs), was observed in the study group. In addition, differences were observed in HDL levels between persons with full Turner's syndrome and those with mosaic variance. Finally, significant difference was observed in the level of triglycerides and in the presence of AASTs and AASMs in treated and untreated persons with mosaic variance.
Metabolic, genetic, eating or autoimmune mechanisms are suspected.
调查患有特纳综合征或嵌合变异型的女孩与同龄健康女孩在医学状况上的差异。此外，还研究了完全型特纳综合征患者与嵌合变异型患者之间是否存在差异。由于研究组中的一些受试者正在接受激素（雌激素和孕激素）治疗，因此治疗的影响也受到关注。调查涉及参与研究人员的心血管异常、骨龄以及血脂和激素水平。
因月经周期问题前来医院就诊的女孩。进行了基因检测（核型分析）。每一位有特纳综合征或嵌合变异型症状的患者都被纳入研究组。对照组纳入每第三位无该综合征症状且年龄相近的患者。
根据参与人员的体重指数进行分层。采用非参数检验进行分析。
研究组中胆固醇、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）和甘油三酯水平存在差异且有所升高。研究组中观察到甲状腺自身抗体、抗甲状腺球蛋白抗体（AAST）和抗微粒体抗体（AASM）的存在。此外，完全型特纳综合征患者与嵌合变异型患者之间的HDL水平存在差异。最后，在接受治疗和未接受治疗的嵌合变异型患者中，甘油三酯水平以及AAST和AASM的存在情况存在显著差异。
怀疑存在代谢、遗传、饮食或自身免疫机制。
