母体给予α-甲基-L-多巴后豚鼠“子宫内”睡眠的改变（作者译）

[Modifications of sleep "in utero" in guinea pig after maternal administration of alpha-methyl-L-DOPA (author's transl)].

作者信息

Astic L, Saucier D

出版信息

Rev Electroencephalogr Neurophysiol Clin. 1977 Jul-Sep;7(3):273-7. doi: 10.1016/s0370-4475(77)80005-1.

Abstract

Effects of maternal administration of alpha-methyl-L-DOPA on sleep in utero were studied by polygraphic method in Guinea Pig faetus from the 53th day of gestation. Maternal injection of alpha-methyl-L-DOPA (100 and 200 mg/kg) produces a typical sedative effect on the faetus from the first hour after drug administration. But, effects appear attenuated in comparison to those of the new-born Guinea Pig: a paradoxical sleep-deprivation of only 30% is observed during the 12 hours period after drug injection. Causes of the attenuation in utero of these drug effects are discussed.

摘要

通过多导记录法，对妊娠第53天的豚鼠胎儿进行研究，以观察母体给予α-甲基-L-多巴对子宫内睡眠的影响。母体注射α-甲基-L-多巴（100和200毫克/千克）后，从给药后第一小时起就对胎儿产生典型的镇静作用。但是，与新生豚鼠相比，这种作用似乎有所减弱：在注射药物后的12小时内，仅观察到30%的反常睡眠剥夺。本文讨论了这些药物作用在子宫内减弱的原因。