Zaffaroni L, Costa P, Spiller M, Vinci G W
Sezione Autonoma per la Sterilità, e la Patologia Ostetrica Ginecologica Funzionale, Ospedale Niguarda Ca' Granda, Milano.
Minerva Ginecol. 1997 Jun;49(6):299-302.
The aim of our study was to evaluate the efficacy and tolerability of vaginal estriol in treating the isolated cervical factor.
Three different groups of patients were selected at random on the basis of the administered therapy (estriol, ethinyl-estradiol, bromhexine associated with gonadotropins). The patients (thirty in all) came to the Autonomous Sterility Department of the Niguarda Ca' Granda Hospital in Milan during the November 1994-January 1996 period. The following parameters were evaluated: cervical score according to Insler, cervical pH; in vivo penetration test (PCT) at third and sixth cycle of treatment; evaluation of the hormonal profile during the ovulatory period of estriol, estradiol, LH and progesterone at the third and sixth cycles of treatment; any possible pregnancy.
On the whole, 23 patients out of 30 (76.6%) had a positive in vivo penetration test. Particularly, a more favourable result was observed in the group to which vaginal estriol was administered as it presented, at treatment end, a positive PCT in 90% of cases. Moreover, always in the latter group, a greater percentage of pregnancies (40%) was observed.
The obtained results have demonstrated that the drug we have studied can be recommended as a valid therapy for the treatment of the isolated cervical factor of sterility.
我们研究的目的是评估阴道雌三醇治疗单纯宫颈因素不孕的疗效和耐受性。
根据所给予的治疗方法（雌三醇、炔雌醇、与促性腺激素联合使用的溴己新）随机选择三组不同的患者。所有30名患者于1994年11月至1996年1月期间前往米兰尼瓜尔达·卡格兰达医院自主不育科就诊。评估了以下参数：根据因斯勒评分法的宫颈评分、宫颈pH值；治疗第三周期和第六周期的体内渗透试验（PCT）；治疗第三周期和第六周期排卵期间雌三醇、雌二醇、促黄体生成素（LH）和孕酮的激素水平评估；任何可能的妊娠情况。
总体而言，30名患者中有23名（76.6%）体内渗透试验呈阳性。特别地，在给予阴道雌三醇的组中观察到了更有利的结果，因为在治疗结束时，该组90%的病例PCT呈阳性。此外，同样在后者组中，观察到更高的妊娠率（40%）。
所获得的结果表明，我们所研究的药物可被推荐作为治疗单纯宫颈因素不孕的有效疗法。
