韩国人群中ABO基因型和等位基因频率的分布。

Distribution of ABO genotypes and allele frequencies in a Korean population.

作者信息

Kang S H, Fukumori Y, Ohnoki S, Shibata H, Han K S, Nishimukai H, Okubo Y

机构信息

Osaka Red Cross Blood Center, Japan.

出版信息

Jpn J Hum Genet. 1997 Jun;42(2):331-5. doi: 10.1007/BF02766955.

DOI:10.1007/BF02766955

PMID:9290258

Abstract

The genotypes of the ABO blood group system were investigated in Korean living in Kangwon-Do area by PCR-RFLP analysis of the seven polymorphic nucleotide positions 261, 467, 526, 646, 703, 796 and 803 of the cDNA from A1 transferase. In 253 unrelated Korean individuals, 15 genotypes were found and the allele frequencies of A(Pro), A(Leu), B, O(T) and O(A) were 0.022, 0.209, 0.209, 0.360 and 0.200, respectively, with no deviation from Hardy-Weinberg expectations (chi 2 = 2.145, d.f. = 6, 0.90 < p < 0.95). As for the distribution of allele frequencies, a significant difference was noticed between the Korean and a Japanese (chi 2 = 30.87, d.f. = 4, p < 0.001) and a German (chi 2 = 127.76, d.f. = 4, p < 0.001) populations.

摘要

通过对A1转移酶cDNA的261、467、526、646、703、796和803这七个多态性核苷酸位点进行PCR-RFLP分析，对生活在江原道地区的韩国人的ABO血型系统基因型进行了研究。在253名无亲缘关系的韩国个体中，发现了15种基因型，A（Pro）、A（Leu）、B、O（T）和O（A）的等位基因频率分别为0.022、0.209、0.209、0.360和0.200，与哈迪-温伯格预期无偏差（χ2 = 2.145，自由度 = 6，0.90 < p < 0.95）。至于等位基因频率的分布，韩国人与日本人（χ2 = 30.87，自由度 = 4，p < 0.001）和德国人（χ2 = 127.76，自由度 = 4，p < 0.001）群体之间存在显著差异。