Clayson E T, Shrestha M P, Vaughn D W, Snitbhan R, Shrestha K B, Longer C F, Innis B L
Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
J Infect Dis. 1997 Sep;176(3):763-6. doi: 10.1086/517296.
To determine hepatitis E virus (HEV) infection and disease rates in the Kathmandu Valley of Nepal, serum was collected from 757 healthy Nepalese (ages 12-48 years) during March and September 1992 and September 1993. At each visit, reports of interval illness were obtained. Sera were examined for IgG to HEV, using a commercially available kit. Seroconversion was used as a marker for HEV infection, and an episode of hepatitis E was defined as a history of jaundice with seroconversion. Seroprevalence ranged from 16% to 31% and increased with age, whereas both infection and disease rates decreased with age. Infection and disease rates were as high as 99/1000 and 45/1000 person-years, respectively. These results highlight the importance of sporadic hepatitis E as a public health problem among adolescents and young adults in this region.
为确定尼泊尔加德满都谷地戊型肝炎病毒（HEV）的感染率和发病率，于1992年3月、9月及1993年9月从757名年龄在12至48岁之间的健康尼泊尔人身上采集血清。每次访视时，均获取期间患病情况报告。使用市售试剂盒检测血清中抗HEV IgG。血清学转换用作HEV感染的标志物，戊型肝炎发作定义为伴有血清学转换的黄疸病史。血清阳性率在16%至31%之间，并随年龄增长而升高，而感染率和发病率均随年龄增长而下降。感染率和发病率分别高达每1000人年99例和45例。这些结果凸显了散发性戊型肝炎作为该地区青少年和年轻人公共卫生问题的重要性。
