尼泊尔加德满都谷戊型肝炎病毒：一项具有代表性的纵向血清学调查的结果。
Hepatitis E virus in the Kathmandu Valley: Insights from a representative longitudinal serosurvey.
机构信息
Research and Development Division, Dhulikhel Hospital Kathmandu University Hospital, Dhulikhel, Nepal.
Center for Infectious Disease Research and Surveillance, Dhulikhel Hospital, Kathmandu University Hospital, Dhulikhel, Nepal.
出版信息
PLoS Negl Trop Dis. 2024 Aug 5;18(8):e0012375. doi: 10.1371/journal.pntd.0012375. eCollection 2024 Aug.
BACKGROUND
Hepatitis-E virus (HEV), an etiologic agent of acute inflammatory liver disease, is a significant cause of morbidity and mortality in South Asia. HEV is considered endemic in Nepal; but data on population-level infection transmission is sparse.
METHODS
We conducted a longitudinal serosurvey in central Nepal to assess HEV exposure. At each visit, capillary blood samples were collected and analyzed for the presence of anti-HEV IgG antibodies. The study took place between February 2019 and April 2021, with up to 4 visits per participant approximately 6 months apart.
RESULTS
We collected 2513 samples from 923 participants aged 0-25 years, finding a seroprevalence of 4.8% and a seroincidence rate of 10.9 per 1000 person-years. Young adults and individuals consuming surface water faced the highest incidence of infection. Geospatial analysis identified potential HEV clusters, suggesting a need for targeted interventions.
SIGNIFICANCE
Our findings demonstrate that HEV is endemic in Nepal and that the risk of infection increases with age.
背景
戊型肝炎病毒（HEV）是一种引起急性炎症性肝病的病原体，是南亚发病率和死亡率的重要原因。HEV 在尼泊尔被认为是地方性的；但关于人群感染传播的数据很少。
方法
我们在尼泊尔中部进行了一项纵向血清学调查，以评估 HEV 暴露情况。在每次访问时，采集毛细血管血样并分析是否存在抗-HEV IgG 抗体。该研究于 2019 年 2 月至 2021 年 4 月进行，每位参与者最多进行 4 次访问，大约每 6 个月一次。
结果
我们从 923 名 0-25 岁的参与者中收集了 2513 个样本，发现血清阳性率为 4.8%，血清发病率为每 1000 人年 10.9 例。年轻人和饮用地表水的个体面临着最高的感染发生率。地理空间分析确定了潜在的 HEV 聚集区，表明需要有针对性的干预措施。
意义
我们的研究结果表明，HEV 在尼泊尔是地方性的，感染风险随着年龄的增长而增加。
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