Moccetti T, Ferrini B, Salvadè G, Rakusa M, Bogenmann F, Riva A, Clara F
Schweiz Med Wochenschr. 1977 Dec 10;107(49):1822-5.
Serum digitalis concentration was measured radioimmunologically on 1006 patients in the period from 1974-1976. The serum levels were correlated with the clinical signs of digitalis toxicity and the indications for determination of the serum digoxin concentration were established. Clinical signs of toxicity appear at a serum level of digoxin above 2.5 ng/ml. Therapeutic limits (range) are most influenced by individual factors. Serum digoxin determination is especially necessary in patients with renal failure and in undisciplined patients with erratic digitalis intake. It is a useful aid in controlling the course of digitalis intoxication, in "low dosage" digitalization and in the case of possible drug interactions.
1974年至1976年期间，采用放射免疫法对1006例患者测定了血清洋地黄浓度。血清水平与洋地黄毒性的临床体征相关，并确定了测定血清地高辛浓度的指征。当血清地高辛水平高于2.5 ng/ml时会出现毒性临床体征。治疗范围（区间）受个体因素影响最大。血清地高辛测定对于肾衰竭患者以及不规律服用洋地黄的患者尤为必要。它有助于控制洋地黄中毒的病程、“小剂量”洋地黄化以及可能存在的药物相互作用情况。
