Marván M L, Santana S, Chávez Chávez L, Bertran M
Departmento de Psicología, Universidad de la Américas-Puebla, Santa Catarina Mártir, México.
Arch Med Res. 1997 Autumn;28(3):369-72.
The forced swimming test is an animal model that is sensitive to the different antidepressant treatments. On the other hand, it is also sensitive to the characteristic changes suffered by animals that have been previously exposed to different depression models. In the present study we explored the effects of inescapable shocks on the forced swimming test, during different phases of the rat estrous cycle. There was an increase of the immobility during diestrus as compared to estrus. Furthermore, inescapable shocks increased the immobility, but only during diestrus. Thus, the differences found between both phases of the estrous cycle were accentuated. Due to the fact that during diestrus there is an absence of progesterone, and that depressed women exacerbate their symptoms during the premenstrual phase, the authors suggest that the immobility registered during the forced swimming test may be useful in the study of premenstrual depression.
强迫游泳试验是一种对不同抗抑郁治疗敏感的动物模型。另一方面，它对先前暴露于不同抑郁模型的动物所经历的特征性变化也很敏感。在本研究中，我们探讨了不可逃避电击在大鼠发情周期不同阶段对强迫游泳试验的影响。与发情期相比，间情期的不动时间增加。此外，不可逃避电击增加了不动时间，但仅在间情期出现这种情况。因此，发情周期两个阶段之间的差异被加剧了。由于间情期不存在孕酮，且抑郁女性在经前期症状会加重，作者认为强迫游泳试验中记录的不动时间可能有助于经前期抑郁症的研究。
