Göldeli O, Ural D, Komsuoğlu B, Ağaçdiken A, Dursun E, Cetinarslan B
Department of Cardiology, Kocaeli University, Medical Faculty, Izmit, Turkey.
Int J Cardiol. 1997 Aug 29;61(1):55-9. doi: 10.1016/s0167-5273(97)00120-4.
Behçet's disease, which was originally described by Hulusi Behçet in 1937, is a generalized chronic inflammatory disease characterized by recurrent oral and genital ulcerations, ocular and dermal manifestations. Cardiac manifestations include pericarditis, myocarditis, conduction system disturbances, coronary arteritis, mitral valve insufficiency, dilated cardiomyopathy, ventricular arrhythmias and sudden cardiac death. There is little knowledge about the mechanism of ventricular arrhythmias in Behçet's disease. In this study, we examined the value of dispersion of ventricular repolarization as a diagnostic tool to assess the risk for ventricular arrhythmias and sudden cardiac death in Behçet's disease. We examined 38 patients (age: 34 +/- 4.6 years, 20F, 18M) with Behçet's disease and 30 age-matched healthy subjects were selected to serve as the control group. Repolarization dispersion parameters were calculated as the difference between maximal and minimal values of QT, QTc, JT and JTC from 12-lead ECG recordings at 25 or 50 mm/s. We found QTd, QTc-d, JTd and JTc-d intervals of 60.65 +/- 16.1, 78.45 +/- 11.4, 71.51 +/- 18.3 and 92.33 +/- 15.4 ms in Behçet's disease patients, these values in control subjects were 40.1 +/- 9.7, 56.36 +/- 7.5, 41.66 +/- 4.3 and 53.92 +/- 9.2 ms respectively (p < 0.001). Striking increases in QT and JT dispersion indicating regional inhomogeneity of ventricular repolarization were noted in patients with Behçet's disease. This new finding suggests a possible explanation for the presence of ventricular arrhythmias in patients with Behçet's disease.
白塞病最初由胡卢西·白塞于1937年描述，是一种全身性慢性炎症性疾病，其特征为复发性口腔和生殖器溃疡、眼部及皮肤表现。心脏表现包括心包炎、心肌炎、传导系统紊乱、冠状动脉炎、二尖瓣关闭不全、扩张型心肌病、室性心律失常及心源性猝死。目前对白塞病中室性心律失常的机制了解甚少。在本研究中，我们检测了心室复极离散度作为评估白塞病患者室性心律失常和心源性猝死风险的诊断工具的价值。我们检查了38例白塞病患者（年龄：34±4.6岁，女性20例，男性18例），并选取30例年龄匹配的健康受试者作为对照组。复极离散度参数计算为25或50mm/s时12导联心电图记录中QT、QTc、JT和JTC的最大值与最小值之差。我们发现白塞病患者的QTd、QTc-d、JTd和JTC-d间期分别为60.65±16.1、78.45±11.4、71.51±18.3和92.33±15.4ms，对照组的这些值分别为40.1±9.7、56.36±7.5、41.66±4.3和53.92±9.2ms（p<0.001）。白塞病患者中QT和JT离散度显著增加，提示心室复极存在区域不均匀性。这一新发现为白塞病患者室性心律失常的存在提供了一种可能的解释。
