Angus B J, Chotivanich K, Udomsangpetch R, White N J
Faculty of Tropical Medicine and Faculty of Science, Department of Pathobiology, Mahidol University, Bangkok, Thailand.
Blood. 1997 Sep 1;90(5):2037-40.
During acute falciparum malaria infection, red blood cells (RBC) containing abundant ring-infected erythrocyte surface antigen (Pf 155 or RESA), but no intracellular parasites, are present in the circulation. These RESA-positive parasite negative RBC are not seen in parasite cultures in vitro. This indicates that in acute falciparum malaria there is active removal of intraerythrocytic parasites by a host mechanism in vivo (probably the spleen) without destruction of the parasitized RBC. This may explain the observed disparity between the drop in hematocrit and decrease in parasite count in some hyperparasitemic patients. The fate of these "once-parasitized" RBC in vivo is not known.
在急性恶性疟原虫感染期间，循环中存在含有大量环状感染红细胞表面抗原（Pf 155或RESA）但无细胞内寄生虫的红细胞（RBC）。这些RESA阳性寄生虫阴性的红细胞在体外寄生虫培养中未见。这表明在急性恶性疟中，宿主机制（可能是脾脏）在体内积极清除红细胞内的寄生虫，而不破坏被寄生的红细胞。这可能解释了一些高疟原虫血症患者中观察到的血细胞比容下降与寄生虫计数减少之间的差异。这些“曾经被寄生”的红细胞在体内的命运尚不清楚。
