Brewer V R, Moore B D, Hiscock M
University of Houston, TX, USA.
J Learn Disabil. 1997 Sep-Oct;30(5):521-33. doi: 10.1177/002221949703000508.
A high incidence of learning disabilities (LD) has been reported in children with neurofibromatosis Type 1 (NF-1), and many children affected with this disease are thought to have a form of LD that is characterized by selective visuospatial and motor deficits. However, the evidence is subject to sampling biases and is limited by the clinical-inferential methods used to classify children into LD subtypes. In the present study, objective statistical methods were used to categorize LD in 105 children with NF-1 between the ages of 6 and 18 years. A cluster analysis of achievement test scores yielded 10 groups; 6 of which met our criterion for academic deficiency. An analysis of neuropsychological data for 72 children with academic deficiencies with complete neuropsychological data yielded three groups: a neuropsychologically normal group (n = 28), a group with general academic deficiencies (n = 34), and a group with visuospatial-construction deficiencies (n = 10). The low incidence of visuospatial-constructional deficits and the absence of cases involving pure linguistic deficits is notable.
据报道，1型神经纤维瘤病（NF-1）患儿中学习障碍（LD）的发病率很高，许多患此病的儿童被认为患有某种形式的学习障碍，其特征是选择性视觉空间和运动缺陷。然而，现有证据存在抽样偏差，并受限于用于将儿童分类为学习障碍亚型的临床推断方法。在本研究中，采用客观统计方法对105名6至18岁的NF-1患儿的学习障碍进行分类。对成绩测试分数进行聚类分析产生了10组；其中6组符合我们的学业不足标准。对72名有学业不足且有完整神经心理学数据的儿童的神经心理学数据进行分析，得出三组：神经心理学正常组（n = 28）、一般学业不足组（n = 34）和视觉空间构建不足组（n = 10）。视觉空间构建缺陷的低发病率以及未出现涉及单纯语言缺陷的病例值得注意。
