乙胺丁醇与β-内酰胺类药物头孢吡肟之间的协同抗分枝杆菌活性。
Synergistic antimycobacterial activity between ethambutol and the beta-lactam drug cefepime.
作者信息
Abate G, Hoffner S E
机构信息
Department of Microbiology and Parasitology, Faculty of Medicine, Addis Ababa University, Ethiopia.
出版信息
Diagn Microbiol Infect Dis. 1997 Jul;28(3):119-22. doi: 10.1016/s0732-8893(97)00012-6.
The activity of cefepime alone and in combination with ethambutol was assessed, using the BACTEC radiometric system, on 33 mycobacterial strains, 14 Mycobacterium avium complex (MAC), 6 isolates of M. malmoense, and 13 multidrug-resistant (MDR) isolates of M. tuberculosis. All tested mycobacteria were resistant to 8 mg/l cefepime. However, at a concentration of 32 mg/l cefepime was active on 7/13 (54%) MDR isolates of M. tuberculosis and 2/6 (33%) M. malmoense strains. All MAC strains were also resistant to this concentration. Synergistic antimycobacterial effects were seen for the combination of cefepime and ethambutol against all isolates of MAC and M. malmoense and on 4/13 (31%) MDR M. tuberculosis isolates. Moreover, this drug combination rendered 17/24 (71%) initially resistant mycobacterial strains susceptible. These promising results suggest that the antimycobacterial activity of combinations of beta-lactam drugs and ethambutol should be studied further.
使用BACTEC放射测量系统，对33株分枝杆菌进行了评估，以测定头孢吡肟单独及与乙胺丁醇联合使用时的活性，其中包括14株鸟分枝杆菌复合群（MAC）、6株马尔默分枝杆菌分离株和13株耐多药（MDR）结核分枝杆菌分离株。所有测试的分枝杆菌对8mg/l的头孢吡肟均耐药。然而，在32mg/l的浓度下，头孢吡肟对13株MDR结核分枝杆菌分离株中的7株（54%）以及6株马尔默分枝杆菌菌株中的2株（33%）有活性。所有MAC菌株对该浓度也耐药。头孢吡肟和乙胺丁醇联合使用对所有MAC和马尔默分枝杆菌分离株以及13株MDR结核分枝杆菌分离株中的4株（31%）具有协同抗分枝杆菌作用。此外，这种药物组合使24株初始耐药的分枝杆菌菌株中的17株（71%）变得敏感。这些有前景的结果表明，β-内酰胺类药物与乙胺丁醇联合使用的抗分枝杆菌活性应进一步研究。
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