Mason P L, Thompson G R
Toxicology. 1977 Oct;8(2):143-56. doi: 10.1016/0300-483x(77)90003-8.
Testicular effects of cyclohexylamine hydrochloride (CHA) were investigated in Wistar and Sprague-Dawley rats. Groups of 25 rats were fed diets containing 6000, 2000 and 600 ppm CHA for 90 days and in addition ad lib., pair-fed and paired-weight control groups were used to assess the role of reduced food intake in the development of testicular lesions. Rats fed diets containing 6000 and 2000 ppm CHA showed significant decreases in food consumption, body weight and body weight gain. However, significant increases in the incidence of testicular lesions were found only in those animals fed 6000 ppm CHA. Absence of a similar incidence of lesions in either the paired-weight of pair-fed control groups indicated that inanition was not primarily responsible for the development of the lesions. The toxicological significane of these findings is discussed.
在Wistar和Sprague-Dawley大鼠中研究了盐酸环己胺（CHA）对睾丸的影响。将25只大鼠分为几组，分别喂食含6000、2000和600 ppm CHA的饲料，持续90天。此外，还设置了自由采食、配对喂食和配对体重对照组，以评估食物摄入量减少在睾丸病变发展中的作用。喂食含6000和2000 ppm CHA饲料的大鼠食物消耗量、体重和体重增加量显著下降。然而，仅在喂食6000 ppm CHA的动物中发现睾丸病变发生率显著增加。配对体重或配对喂食对照组中未出现类似的病变发生率，这表明饥饿不是病变发展的主要原因。讨论了这些发现的毒理学意义。
