Devouassoux Shishe Boran M, Grange J D, Patricot L M, Adeleine P, Chauvel P, Chiquet C, Vitrey D, Thivolet Béjui F
Laboratoratoire d'Anatomie et de Cytologie Pathologiques, Hopital de la Croix Rousse, Lyon.
Ann Pathol. 1997 Jul;17(3):187-92.
To evaluate irradiation effects on choroidal melanomas, histopathologic findings of 18 eyes whose primary treatment was enucleation were compared to 15 eyes enucleated after proton beam irradiation. Irradiated tumors showed more likely necrosis (p = 0.01) had balloon cells (p = 0.01), and inflammatory infiltrate (p = 0.05). In the irradiated group, the prevalence of tumor blood vessel damage was higher (p = 0.0002) and mitotic figures were fewer (p = 0.01). These findings suggest that proton beam irradiation damages tumor cells and alters the tumor's capacity for cellular reproduction. It damages blood vessels leading to tumor necrosis. It induces an inflammatory response of unknown effects. Radiosensitivity of choroidal melanomas cannot be assessed using conventional histologic methods. However, tumor necrosis, mitotic activity and rate of balloon cells can help to establish tumoral sensitivity to irradiation.
为评估放疗对脉络膜黑色素瘤的影响，将18只以眼球摘除为主要治疗方式的眼睛的组织病理学结果与15只质子束放疗后眼球摘除的眼睛进行比较。接受放疗的肿瘤更易出现坏死（p = 0.01）、气球样细胞（p = 0.01）和炎性浸润（p = 0.05）。在放疗组中，肿瘤血管损伤的发生率更高（p = 0.0002），有丝分裂象更少（p = 0.01）。这些发现表明，质子束放疗会损伤肿瘤细胞并改变肿瘤的细胞增殖能力。它会损伤血管导致肿瘤坏死。它会引发具有未知效应的炎症反应。脉络膜黑色素瘤的放射敏感性无法用传统组织学方法评估。然而，肿瘤坏死、有丝分裂活性和气球样细胞比例有助于确定肿瘤对放疗的敏感性。
