Spetzger U, Rohde V, Gilsbach J M
Neurochirurgischen Universitätsklinik, RWTH Aachen, Deutschland.
Wien Med Wochenschr. 1997;147(7-8):172-7.
The treatment of cerebral aneurysms aims at the complete elimination of the aneurysm from the circulation. In the case of subarachnoid hemorrhage (SAH), early management prevents rebleeding and in incidental aneurysms, future rupture is to be prevented. Standardization of surgical techniques and optimized collateral measures have reduced the morbidity and mortality of early operations in SAH to 10% and 15%, respectively, in most series. As an alternative, endovascular techniques are being developed which attempt to obliterate the aneurysmal sack by packing it with detachable platinum-coils. A major difference between clipping and coiling is the closure of the aperture by the surgical clip which approximates the vessel walls. During coil embolization, that aperture stays open, allowing in some cases further compaction of the coils in subsequent months and years. Recanalization attributable to compaction depends on the size of the aneurysm and may necessitate repacking in up to 40% of the cases (aneurysms > 25 mm). As for the risk of rebleeding, a recanalized aneurysm is comparable to a partially clipped aneurysm. As the surgical results from early and delayed operations were obtained in randomized controlled studies, such randomized comparative studies will need to be applied to assess the value and risks and long-term results of endovascular strategies.
脑动脉瘤的治疗旨在从血液循环中彻底消除动脉瘤。对于蛛网膜下腔出血(SAH)患者,早期治疗可预防再出血;对于偶然发现的动脉瘤,则需预防其未来破裂。在大多数病例系列中,手术技术的标准化和优化的辅助措施已将SAH早期手术的发病率和死亡率分别降至10%和15%。作为一种替代方法,正在开发血管内技术,试图通过用可脱卸的铂线圈填充动脉瘤囊来使其闭塞。夹闭术和线圈栓塞术的一个主要区别在于,手术夹会闭合动脉瘤开口,使血管壁相互靠近。而在进行线圈栓塞时,该开口保持开放,在某些情况下,这会使线圈在随后的数月和数年中进一步压实。因压实导致的再通取决于动脉瘤的大小,在高达40%的病例(动脉瘤>25mm)中可能需要重新填充。至于再出血风险,再通的动脉瘤与部分夹闭的动脉瘤相当。由于早期和延迟手术的结果是在随机对照研究中获得的,因此需要应用此类随机对照研究来评估血管内治疗策略的价值、风险和长期效果。