Joneson T, Bar-Sagi D
Department of Molecular Genetics and Microbiology, State University of New York at Stony Brook 11794, USA.
J Mol Med (Berl). 1997 Aug;75(8):587-93. doi: 10.1007/s001090050143.
Ras proteins are membrane-bound GTP-binding proteins that play a critical role in the control of cell growth. Through a large number of genetic and biochemical studies it is becoming increasingly evident that the biological activity of Ras proteins is mediated by multiple signaling pathways. This review provides an account of the target proteins that interact with Ras and the functional consequences of these interactions. The relative contribution of the different Ras effector pathways to the mitogenic and oncogenic effects of Ras are discussed.
Ras蛋白是膜结合的GTP结合蛋白，在细胞生长控制中起关键作用。通过大量的遗传学和生物化学研究，越来越明显的是，Ras蛋白的生物学活性是由多种信号通路介导的。这篇综述介绍了与Ras相互作用的靶蛋白以及这些相互作用的功能后果。讨论了不同的Ras效应通路对Ras的促有丝分裂和致癌作用的相对贡献。
