Edwards W D, Thomas J A
Urol Int. 1977;32(4):303-11. doi: 10.1159/000280146.
When testosterone (T) or dihydrotestosterone (DHT) pellets (15 mg) were implanted into host male rats of different ages bearing ventral prostate transplants obtained from donors of varying ages, the in situ tissues generally contained more DNA than did the transplanted tissues. Hosts implanted with T, and in particular in the transplanted ventral prostate tissues, contained higher levels of DNA than in those host implanted with DHT. Neither the donor or host age (6-12 weeks) nor the duration of the transplant (6 or 12 weeks) seemed to have any demonstrable effect upon the levels of DNA in the transplant itself or in the in situ prostate. The in vitro incubations of slices of either the transplant or the host's prostate with testosterone-3H revealed that both tissues could effectively synthesize dihydrotestosterone-3H and androstanediol-3H. However, the transplanted tissues was less capable of such steroid metabolism, and overall was 1/3-1/2 as effective as the host prostate tissues in vitro. The acinar epithelial cell heights and the cellular secretory activities in the transplants were often similar to those examined from the host's in situ ventral prostate. Prolactin (50 IU/kg daily X 5) did not affect DNA levels in either the transplants or the in situ prostate, but this hormone did accelerate the formation of DHT-3H in the situ prostate in vitro.
当将睾酮（T）或二氢睾酮（DHT）丸剂（15毫克）植入不同年龄的雄性宿主大鼠体内时，这些宿主带有从不同年龄供体获得的腹侧前列腺移植组织，原位组织中的DNA含量通常比移植组织中的多。植入T的宿主，尤其是移植的腹侧前列腺组织中的DNA水平，高于植入DHT的宿主。供体或宿主的年龄（6 - 12周）以及移植的持续时间（6或12周）似乎对移植组织本身或原位前列腺中的DNA水平没有任何明显影响。用睾酮 - 3H对移植组织或宿主前列腺切片进行体外孵育，结果显示两种组织都能有效合成二氢睾酮 - 3H和雄烷二醇 - 3H。然而，移植组织进行这种类固醇代谢的能力较弱，总体而言，在体外其效力仅为宿主前列腺组织的1/3 - 1/2。移植组织中的腺泡上皮细胞高度和细胞分泌活性通常与宿主原位腹侧前列腺中的相似。催乳素（每日50国际单位/千克×5天）对移植组织或原位前列腺中的DNA水平没有影响，但这种激素确实能在体外加速原位前列腺中DHT - 3H的形成。
