Yamada T, Tsuboi Y, Takahashi M
Department of Neurology, Chiba University, Japan.
Dement Geriatr Cogn Disord. 1997 Sep-Oct;8(5):267-72. doi: 10.1159/000106643.
Complement-activated oligodendroglia (CAOs) are thought to represent complement bearing damaged oligodendroglia for opsonization. The interrelationship between CAOs and amyloid deposits was examined by immunohistochemistry in the parietal lobe of patients with Parkinson's disease, diffuse Lewy body disease, and pallido-nigro-luysial atrophy. In all brains, the anti-C4d antibody stained numerous CAOs. Anti-beta-amyloid protein (anti-A beta) antibody revealed moderate numbers of senile plaques, including some of the classical type. In both the grey and the white matter amyloid deposits were frequently associated with the myelinated axons of CAOs. CAOs were occasionally associated with phagocytosing microglial cells. Immunoelectron microscopy also showed a close relationship between phagocytosing microglia and A beta deposition. On some occasions. A beta deposits were seen in C4d-positive oligodendroglial cell bodies. These results indicate that damaged myelinated axons, which contain accumulated amyloid precursor protein, are the source of A beta, and that CAOs may be initial targets for A beta deposits forming the classical senile plaques.
补体激活的少突胶质细胞（CAOs）被认为是带有补体的受损少突胶质细胞，用于调理作用。通过免疫组织化学方法，在帕金森病、弥漫性路易体病和苍白球-黑质-路易体萎缩患者的顶叶中，研究了CAOs与淀粉样沉积物之间的相互关系。在所有大脑中，抗C4d抗体均能染色大量的CAOs。抗β-淀粉样蛋白（抗Aβ）抗体显示出中等数量的老年斑，包括一些经典类型。在灰质和白质中，淀粉样沉积物经常与CAOs的有髓轴突相关。CAOs偶尔与吞噬性小胶质细胞相关。免疫电子显微镜也显示吞噬性小胶质细胞与Aβ沉积之间存在密切关系。在某些情况下，在C4d阳性的少突胶质细胞胞体中可见Aβ沉积物。这些结果表明，含有积累的淀粉样前体蛋白的受损有髓轴突是Aβ的来源，并且CAOs可能是形成经典老年斑的Aβ沉积物的初始靶点。
