Yamada T, McGeer P L
Department of Psychiatry, University of British Columbia, Vancouver, Canada.
Neurosci Lett. 1990 Dec 11;120(2):163-6. doi: 10.1016/0304-3940(90)90028-8.
Oligodendroglial microtubular masses (OMMs) were identified immunohistochemically in brain tissue from patients with such degenerative disorders as Alzheimer disease, Pick's disease and argyrophilic grain dementia. The OMMs were identified by Alz-50 and antibodies to Tau-2, paired helical filaments and ubiquitin. They occurred preferentially in white matter. They were composed of fibers 25 nm in diameter and were localized to the cytoplasma of oligodendroglia and processes of oligodendroglia ensheathing damaged axons. They sometimes occurred in oligodendroglia also stained by antibody to the complement protein C4d. These data suggest that OMMs represent abnormal microtubular accumulations in oligodendroglia, possibly as a reaction to axonal damage.
在患有诸如阿尔茨海默病、皮克病和嗜银颗粒性痴呆等退行性疾病患者的脑组织中，通过免疫组织化学方法鉴定出了少突胶质细胞微管团块（OMMs）。OMMs通过Alz - 50以及针对Tau - 2、双螺旋丝和泛素的抗体进行鉴定。它们优先出现在白质中。它们由直径为25纳米的纤维组成，定位于少突胶质细胞的细胞质以及包裹受损轴突的少突胶质细胞突起中。它们有时也出现在用补体蛋白C4d抗体染色的少突胶质细胞中。这些数据表明，OMMs代表少突胶质细胞中异常的微管聚集，可能是对轴突损伤的一种反应。
