Barker D J
MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, UK.
Acta Paediatr Suppl. 1997 Jul;422:78-82. doi: 10.1111/j.1651-2227.1997.tb18351.x.
Animal studies have shown that undernutrition before birth programmes persisting changes in a range of metabolic, physiological and structural parameters. Studies in humans have shown that men and women whose birthweights were at the lower end of the normal range, who were thin or short at birth or small in relation to placental size have increased rates of coronary heart disease. We are beginning to understand something of the mechanisms underlying these associations.
动物研究表明，出生前营养不良会导致一系列代谢、生理和结构参数持续发生变化。对人类的研究表明，出生体重处于正常范围下限、出生时体型瘦小或相对于胎盘大小较小的男性和女性患冠心病的几率更高。我们开始逐渐了解这些关联背后的一些机制。
