Tewari K, Brewer C, Cappuccini F, Macri C, Rogers L W, Berman M L
Department of Obstetrics and Gynecology, University of California at Irvine-Medical Center, 101 The City Drive, Orange, California 92868, USA.
Gynecol Oncol. 1997 Sep;66(3):531-4. doi: 10.1006/gyno.1997.4801.
We report the longest disease-free survival achieved in an advanced-stage small cell carcinoma of the ovary. The patient had a stage IIIc tumor diagnosed during pregnancy. She underwent a total abdominal hysterectomy, bilateral salpingo-oophorectomy, omentectomy, and optimal tumor debulking. Following her immediate postoperative recovery, she was treated with a multiagent chemotherapy regimen with germ cell activity consisting of vinblastine, cisplatin, cyclophosphamide, bleomycin, doxorubicin, and etoposide. She is alive and without evidence of disease 5(1/2) years after diagnosis. This is the second reported case in pregnancy and the longest disease-free survivor of metastatic small cell ovarian carcinoma in the medical literature.
我们报告了晚期卵巢小细胞癌患者实现的最长无病生存期。该患者在孕期被诊断为Ⅲc期肿瘤。她接受了全腹子宫切除术、双侧输卵管卵巢切除术、大网膜切除术以及最佳肿瘤减瘤术。术后即刻恢复后，她接受了由长春碱、顺铂、环磷酰胺、博来霉素、多柔比星和依托泊苷组成的具有生殖细胞活性的多药化疗方案。诊断后5年半，她仍存活且无疾病迹象。这是医学文献中报道的第二例孕期病例，也是转移性卵巢小细胞癌最长的无病生存者。
