Goldbloom D S, Olmsted M, Davis R, Clewes J, Heinmaa M, Rockert W, Shaw B
Clarke Institute of Psychiatry, Toronto, Ontario, Canada.
Behav Res Ther. 1997 Sep;35(9):803-11. doi: 10.1016/s0005-7967(97)00041-7.
This study compared and combined fluoxetine and individual cognitive behavioral therapy in the treatment of bulimia nervosa. Participants were 76 women who sought treatment at the Eating Disorders Program of the Toronto Hospital and who met DSM-III-R criteria for bulimia nervosa. Subjects were randomly assigned to receive fluoxetine alone, cognitive behavior therapy alone, or the two in combination and were treated over 16 weeks. Short-term outcome revealed that all three treatment conditions were associated with clinical improvement across a wide range of parameters. The combination of pharmacotherapy and psychotherapy was superior to pharmacotherapy alone on specific parameters and there was no statistically significant advantage to the combination over psychotherapy alone. Limitations to the study include the absence of a placebo pill group and a waiting list control group as well as a substantial dropout rate across all three treatment conditions.
本研究比较并联合使用氟西汀与个体认知行为疗法来治疗神经性贪食症。参与者为76名在多伦多医院饮食失调项目寻求治疗且符合DSM-III-R神经性贪食症标准的女性。受试者被随机分配为单独接受氟西汀治疗、单独接受认知行为疗法治疗或两者联合治疗，并接受为期16周的治疗。短期结果显示，所有三种治疗条件在广泛的参数范围内均与临床改善相关。药物治疗与心理治疗联合在特定参数上优于单独的药物治疗，且联合治疗相对于单独的心理治疗并无统计学上的显著优势。该研究的局限性包括缺乏安慰剂组和等待名单对照组，以及所有三种治疗条件下均有相当高的脱落率。
