Marino F, Cosentino M, Bombelli R, Ferrari M, Maestroni G J, Conti A, Lecchini S, Frigo G
Department of Internal Medicine and Therapeutics, II Faculty of Medicine, University of Pavia, Varese, Italy.
Haematologica. 1997 Jul-Aug;82(4):392-4.
Noradrenergic innervation is present in the bone marrow and adrenergic agents can modulate hematopoiesis. However, since no data are available concerning endogenous catecholamines at this level, we investigated their presence and origin.
Using a high performance liquid chromatographic method, we have and measured endogenous catecholamines in bone marrow from normal, 6-OHDA-treated and pargyline-treated mice.
Noradrenaline, adrenaline and dopamine levels were, respectively, 2806.74 +/- 408.85, 803.37 +/- 87.66 and 274.47 +/- 51.54 pg/g of tissue. Noradrenaline levels were lower after 6-OHDA (1130.47 +/- 142.73 pg/g of tissue, p < 0.01 vs. control values) and higher after pargyline (4122.62 +/- 509.54 pg/g of tissue, p < 0.05). None of these treatments significantly affected adrenaline or dopamine content.
Noradrenaline in the bone marrow originates mainly from sympathetic nerve endings and is metabolized through specific enzymatic pathways. Adrenaline and dopamine may originate from other sources, such as the systemic circulation.
去甲肾上腺素能神经支配存在于骨髓中，且肾上腺素能药物可调节造血作用。然而，由于目前尚无关于该水平内源性儿茶酚胺的相关数据，我们对其存在情况及来源进行了研究。
我们采用高效液相色谱法，对正常小鼠、经6-羟基多巴胺（6-OHDA）处理的小鼠和经帕吉林处理的小鼠的骨髓中的内源性儿茶酚胺进行了测定。
去甲肾上腺素、肾上腺素和多巴胺水平分别为2806.74±408.85、803.37±87.66和274.47±51.54 pg/g组织。6-OHDA处理后去甲肾上腺素水平降低（1130.47±142.73 pg/g组织，与对照值相比p<0.01），帕吉林处理后升高（4122.62±509.54 pg/g组织，p<0.05）。这些处理均未显著影响肾上腺素或多巴胺含量。
骨髓中的去甲肾上腺素主要源自交感神经末梢，并通过特定的酶促途径进行代谢。肾上腺素和多巴胺可能源自其他来源，如体循环。
