Kaga A, Nakano T, Hori S, Kamida T, Isono M, Kasai N
Department of Neurosurgery, Medical University of Oita.
No Shinkei Geka. 1997 Sep;25(9):803-7.
A 65-year-old man who had a history of diabetes mellitus visited a hospital for recent memory disturbance. MR angiography showed stenoses of the main trunks of the intracranial arteries. He was admitted to our hospital, and angiography revealed occlusion of the left cervical internal carotid and right middle cerebral arteries, and stenoses of the right internal carotid, right anterior cerebral, left vertebral, and right posterior cerebral arteries. There was collateral circulation formed from the left external carotid and left posterior cerebral arteries. Basal moyamoya vessels were also observed. 123I-IMP SPECT showed low perfusion of the right cerebral hemisphere, and response to acetazolamide was poor. Based on the angiographical findings and the presence of diabetes mellitus, the patient was diagnosed as having quasi-moyamoya disease. Vascular reconstructive surgery was indicated. Since there was no recipient artery adequate for STA-MCA anastomosis, encephalo-duro-arterio-synangiosis was performed on the right side. Postoperatively, the patient's recent memory improved gradually, and angiography performed 7 months after the operation revealed neovascularization from the superficial and deep temporal arteries. Although indirect bypass surgery has been applied mainly to child moyamoya disease, its effectiveness for cerebral ischemia in adult patients has also been reported, particularly in cases with misery perfusion. Neovascularization with indirect bypass surgery can be expected if the patient is under misery perfusion, even in elderly patients.
一名有糖尿病病史的65岁男性因近期记忆障碍前往医院就诊。磁共振血管造影显示颅内动脉主干狭窄。他被收治入我院,血管造影显示左侧颈内动脉和右侧大脑中动脉闭塞,右侧颈内动脉、右侧大脑前动脉、左侧椎动脉和右侧大脑后动脉狭窄。存在由左侧颈外动脉和左侧大脑后动脉形成的侧支循环。还观察到基底烟雾状血管。123I-IMP单光子发射计算机断层扫描显示右侧大脑半球灌注减低,对乙酰唑胺的反应不佳。根据血管造影结果及糖尿病的存在,该患者被诊断为准烟雾病。建议行血管重建手术。由于没有适合颞浅动脉-大脑中动脉吻合的受体动脉,遂在右侧行脑-硬膜-动脉-血管融合术。术后,患者近期记忆逐渐改善,术后7个月行血管造影显示颞浅动脉和颞深动脉有新生血管形成。尽管间接搭桥手术主要应用于儿童烟雾病,但也有报道称其对成年患者脑缺血有效,尤其是在存在严重灌注不良的情况下。即使是老年患者,若处于严重灌注不良状态,间接搭桥手术有望实现新生血管形成。