Lovric V A, Prince B, Bryant J
Vox Sang. 1977 Dec;33(6):346-52. doi: 10.1111/j.1423-0410.1977.tb02255.x.
Various anticoagulant-preservative solutions were investigated with a view to determining which would give optimal shelf life of packed cells. Satisfactory 24-hour post-transfusion survival (greater than 70%) after 28-day storage was obtained with citrate phosphate 277 mM dextrose, 0.25 mM adenine (CP2 X D-adenine). After addition of a rejuvenating electrolyte solution through a multiple closed plastic pack system, there was further improvement in viability, oxygen delivery capacity and metabolic activity of stored erythrocytes, with reduction in both plasma potassium and microaggregate numbers. No untoward reactions were observed during or after transfusion of 440 units of rejuvenated blood.
为了确定哪种抗凝保存液能使红细胞悬液达到最佳保存期限，对多种抗凝保存液进行了研究。使用含有277 mM柠檬酸盐、磷酸盐、葡萄糖和0.25 mM腺嘌呤的抗凝保存液（CP2X D -腺嘌呤），在储存28天后进行输血，能获得令人满意的24小时后输血存活率（大于70%）。通过多封闭塑料包装系统加入复苏电解质溶液后，储存红细胞的活力、氧输送能力和代谢活性进一步提高，同时血浆钾含量和微聚集体数量减少。在输注440单位复苏血液的过程中及之后，均未观察到不良反应。
