Kraemer P J, Randall C K, Dose J M, Brown R W
Department of Psychology, University of Kentucky, Lexington 40506, USA.
Pharmacol Biochem Behav. 1997 Oct;58(2):323-7. doi: 10.1016/s0091-3057(97)00296-7.
The influence of d-amphetamine on timing in pigeons was examined with a production procedure. Birds were trained with a fixed time schedule in which food reinforcement was contingent on the first response made after a duration signal had appeared for 30 s. Probe tests involved trials in which the duration signal was extended to 90 s and reinforcement was omitted. In Experiment 1, 2.0 mg/kg d-amphetamine shifted peak responding to a duration shorter than that found with saline. In Experiment 2, the dose-response function for this drug effect was examined. A 0.3-mg/kg dose of d-amphetamine had no impact on performance, but a 1.0-mg/kg dose shifted the peak duration significantly relative to saline; a 2.0-mg/kg dose shifted the function even more. These results complement previous findings with rats tested with the peak procedure and pigeons tested with a discrimination procedure.
用一种生产程序研究了d-苯丙胺对鸽子计时的影响。鸟类接受固定时间安排的训练，在持续信号出现30秒后，首次做出反应就给予食物强化。探测测试包括将持续信号延长至90秒且不给予强化的试验。在实验1中，2.0毫克/千克的d-苯丙胺使峰值反应转移到比生理盐水组更短的持续时间。在实验2中，研究了这种药物效应的剂量反应函数。0.3毫克/千克剂量的d-苯丙胺对行为表现没有影响，但1.0毫克/千克剂量相对于生理盐水显著改变了峰值持续时间；2.0毫克/千克剂量使该函数变化更大。这些结果补充了之前用峰值程序测试大鼠和用辨别程序测试鸽子的研究结果。
