Hostacká A, Karelová E
Institute of Preventive and Clinical Medicine, Bratislava, Slovak Republic.
Microbios. 1997;90(362):45-50.
A suppression of bacterial growth of three Pseudomonas aeruginosa strains after 30 min treatment with imipenem at supra-inhibitory concentrations (post-antibiotic effect; PAE) was observed. Imipenem (4x MIC) showed PAEs in the range of 0.5-0.9 h for stains studied. The PAEs manifested by imipenem at 8x MIC concentration varied between 2.4 and 4.0 h. Supra-inhibitory concentrations of imipenem did not affect the profiles of the outer membrane proteins of the stains. The treated strains revealed the same protein bands (45, 38, 35 and 23 kD) compared with controls.
观察到在超抑制浓度下用亚胺培南处理30分钟后，三种铜绿假单胞菌菌株的细菌生长受到抑制（抗生素后效应；PAE）。亚胺培南（4倍MIC）对所研究的菌株显示出0.5 - 0.9小时的PAE。亚胺培南在8倍MIC浓度下表现出的PAE在2.4至4.0小时之间。亚胺培南的超抑制浓度不影响菌株外膜蛋白的图谱。与对照相比，处理后的菌株显示出相同的蛋白条带（45、38、35和23 kD）。
