Choi Eun-Su, Jeong Woo-Jin, Ahn Soon-Hyun, Oh Ah-Young, Jeon Young-Tae, Do Sang-Hwan
Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, 82, Gumi-ro 173 beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do, South Korea.
Department of Otorhinolaryngology Head and Neck Surgery, Seoul National University Bundang Hospital, 82, Gumi-ro 173 beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do, South Korea.
J Clin Anesth. 2017 Feb;36:102-106. doi: 10.1016/j.jclinane.2016.10.020. Epub 2016 Dec 1.
We evaluated the effect of magnesium sulfate-an enhancer of neuromuscular blockade-on onset and duration of low dose of rocuronium, and on operating conditions during laryngeal microsurgery.
Randomized, prospective, double-blinded study.
Eighty-four patients scheduled for elective laryngeal microsurgery.
Patients were randomly allocated to receive different doses of rocuronium: 0.6 mg/kg (group C, n=28), 0.45 mg/kg (group LR, n=28), or 0.45 mg/kg plus magnesium sulfate 30 mg/kg (group LM, n=28).
We measured the onset time and duration of action of rocuronium, and evaluated the surgeon's satisfaction with the operating conditions.
Group LR showed significantly delayed onset time (group C: 87±22 seconds, group LR: 127±47 seconds, and group LM: 89±32 seconds; P=.001) and maximal suppression than did other groups (group C: 102±30 seconds, group LR: 155±66 seconds, and group LM: 105±36 seconds; P=.002). Duration of action of rocuronium was significantly longer in group C than in other groups (group C: 39±7 minutes, group LR: 28±8 minutes, group LRM: 31±8 minutes; P<.001). Laryngoscope placement score (P=.002), surgeon's satisfaction (P=.005), and sore throat (P=.035) were significantly worse in group LR.
Magnesium sulfate 30 mg/kg accelerated the onset and improved operating conditions of low-dose rocuronium without prolongation of action.
我们评估了硫酸镁（一种神经肌肉阻滞增强剂）对低剂量罗库溴铵起效时间和作用持续时间的影响，以及对喉显微手术术中情况的影响。
随机、前瞻性、双盲研究。
84例计划行择期喉显微手术的患者。
患者被随机分配接受不同剂量的罗库溴铵：0.6mg/kg（C组，n = 28）、0.45mg/kg（LR组，n = 28）或0.45mg/kg加30mg/kg硫酸镁（LM组，n = 28）。
我们测量了罗库溴铵的起效时间和作用持续时间，并评估了外科医生对术中情况的满意度。
LR组的起效时间显著延迟（C组：87±22秒，LR组：127±47秒，LM组：89±32秒；P = 0.001），且最大肌松程度高于其他组（C组：102±30秒，LR组：155±66秒，LM组：105±36秒；P = 0.002）。C组罗库溴铵的作用持续时间显著长于其他组（C组：39±7分钟，LR组：28±8分钟，LRM组：31±8分钟；P<0.001）。LR组的喉镜置入评分（P = 0.002）、外科医生满意度（P = 0.005）和咽痛（P = 0.035）明显更差。
30mg/kg硫酸镁可加速低剂量罗库溴铵的起效并改善术中情况，且不延长其作用时间。
